Meldgaard, M; Kristensen, R S; Z'Graggen, W J; Tan, S V; Søndergaard, K; Qerama, E; Andersen, H; Fuglsang-Frederiksen, A; Tankisi, H (2023). Muscle velocity recovery cycles in myopathy. Clinical neurophysiology, 151, pp. 41-49. Elsevier 10.1016/j.clinph.2023.04.001
|
Text
1-s2.0-S1388245723005965-main.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
OBJECTIVE
To understand the pathophysiology of myopathies by using muscle velocity recovery cycles (MVRC) and frequency ramp (RAMP) methodologies.
METHODS
42 patients with quantitative electromyography (qEMG) and biopsy or genetic verified myopathy and 42 healthy controls were examined with qEMG, MVRC and RAMP, all recorded from the anterior tibial muscle.
RESULTS
There were significant differences in the motor unit potential (MUP) duration, the early and late supernormalities of the MVRC and the RAMP latencies in myopathy patients compared to controls (p < 0.05 apart from muscle relatively refractory period (MRRP)). When dividing into subgroups, the above-mentioned changes in MVRC and RAMP parameters were increased for the patients with non-inflammatory myopathy, while there were no significant changes in the group of patients with inflammatory myopathy.
CONCLUSIONS
The MVRC and RAMP parameters can discriminate between healthy controls and myopathy patients, more significantly for non-inflammatory myopathy. MVRC differences with normal MRRP in myopathy differs from other conditions with membrane depolarisation.
SIGNIFICANCE
MVCR and RAMP may have a potential in understanding disease pathophysiology in myopathies. The pathogenesis in non-inflammatory myopathy does not seem to be caused by a depolarisation of the resting membrane potential but rather by the change in sodium channels of the muscle membrane.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Z'Graggen, Werner Josef |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1872-8952 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
08 May 2023 12:44 |
Last Modified: |
08 May 2023 12:53 |
Publisher DOI: |
10.1016/j.clinph.2023.04.001 |
PubMed ID: |
37148747 |
Uncontrolled Keywords: |
Electromyography Frequency ramp Inflammatory myopathy Muscle velocity recovery cycles Non-inflammatory myopathy |
BORIS DOI: |
10.48350/182376 |
URI: |
https://boris.unibe.ch/id/eprint/182376 |
Actions (login required)
 |
Edit item |