Triumbari, Elizabeth Katherine Anna; Rufini, Vittoria; Mingels, Clemens; Rominger, Axel; Alavi, Abass; Fanfani, Francesco; Badawi, Ramsey D; Nardo, Lorenzo (2023). Long Axial Field-of-View PET/CT Could Answer Unmet Needs in Gynecological Cancers. Cancers, 15(9) MDPI AG 10.3390/cancers15092407
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Gynecological malignancies currently affect about 3.5 million women all over the world. Imaging of uterine, cervical, vaginal, ovarian, and vulvar cancer still presents several unmet needs when using conventional modalities such as ultrasound, computed tomography (CT), magnetic resonance, and standard positron emission tomography (PET)/CT. Some of the current diagnostic limitations are represented by differential diagnosis between inflammatory and cancerous findings, detection of peritoneal carcinomatosis and metastases <1 cm, detection of cancer-associated vascular complications, effective assessment of post-therapy changes, as well as bone metabolism and osteoporosis assessment. As a result of recent advances in PET/CT instrumentation, new systems now offer a long-axial field-of-view (LAFOV) to image between 106 cm and 194 cm (i.e., total-body PET) of the patient's body simultaneously and feature higher physical sensitivity and spatial resolution compared to standard PET/CT systems. LAFOV PET could overcome the forementioned limitations of conventional imaging and provide valuable global disease assessment, allowing for improved patient-tailored care. This article provides a comprehensive overview of these and other potential applications of LAFOV PET/CT imaging for patients with gynecological malignancies.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Mingels, Clemens, Rominger, Axel Oliver |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2072-6694 |
Publisher: |
MDPI AG |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
15 May 2023 15:00 |
Last Modified: |
16 May 2023 15:36 |
Publisher DOI: |
10.3390/cancers15092407 |
PubMed ID: |
37173874 |
Uncontrolled Keywords: |
PET/CT gynecological long axial field of view oncology total body unmet needs |
BORIS DOI: |
10.48350/182535 |
URI: |
https://boris.unibe.ch/id/eprint/182535 |
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