Exploring group differences in the response to a sexual risk reduction intervention to prevent hepatitis C virus reinfection in HIV-infected MSM: a mixed-methods study.

Künzler-Heule, Patrizia; Schmidt, Axel J; Fierz, Katharina; Battegay, Manuel; Engberg, Sandra; Kouyos, Roger D; Nöstlinger, Christiana; Stöckle, Marcel; Béguelin, Charles; Delaloye, Julie; Schmid, Patrick; Rougemont, Mathieu; Braun, Dominique L; Fehr, Jan S; Nicca, Dunja (2023). Exploring group differences in the response to a sexual risk reduction intervention to prevent hepatitis C virus reinfection in HIV-infected MSM: a mixed-methods study. (In Press). AIDS Care-Psychological and Socio-Medical Aspects of AIDS/HIV, pp. 1-10. Taylor & Francis 10.1080/09540121.2023.2208318

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To prevent hepatitis C virus (HCV) reinfection, within the Swiss HCVree Trial, a preventive risk reduction intervention was implemented alongside curative treatment. Formative qualitative research identified three response patterns to the intervention. This mixed-methods study's aim was to cross-validate group differences in (a) the content of sexual risk reduction goals set during intervention and (b) the extent of their behavioural change in condomless anal intercourse with non-steady partners (nsCAI), sexualised and intravenous drug use at start and six-month post-intervention. Qualitative thematic analysis was used to summarise goal setting domains. Quantitative descriptive analysis was used to evaluate group differences based on assumptions of the group descriptions. Results largely confirmed assumptions on inter-group response differences in goal setting and behaviour: as expected group 1 Avoid risks showed the lowest HCV risk profile with changes in nsCAI. Group 2 Minimize-risks and Group 3 Accept-risks showed unchanged nsCAI. Group 3 had the highest HCV risk profile. Differences in their goal preferences (1: condom use; 2 reduction blood exposure; 3 safer dating) highlight diversity in attitudes to behavioural change. Our results improve understanding of variability in intervention responses such as changes in attitudes and behaviour. This provides evidence for intervention tailoring and outcome measurement.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Béguelin, Charles Antoine

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0954-0121

Publisher:

Taylor & Francis

Language:

English

Submitter:

Pubmed Import

Date Deposited:

15 May 2023 08:40

Last Modified:

15 May 2023 08:40

Publisher DOI:

10.1080/09540121.2023.2208318

PubMed ID:

37182220

Uncontrolled Keywords:

HIV infections Homosexuality NCT02785666 harm reduction hepatitis C male sex counselling

URI:

https://boris.unibe.ch/id/eprint/182546

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