Trnkova, Petra; Zhang, Ye; Toshito, Toshiyuki; Heijmen, Ben; Richter, Christian; Aznar, Marianne C; Albertini, Francesca; Bolsi, Alessandra; Daartz, Juliane; Knopf, Antje C; Bertholet, Jenny (2023). A survey of practice patterns for adaptive particle therapy for interfractional changes. Physics and imaging in radiation oncology, 26, p. 100442. Elsevier 10.1016/j.phro.2023.100442
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BACKGROUND AND PURPOSE
Anatomical changes may compromise the planned target coverage and organs-at-risk dose in particle therapy. This study reports on the practice patterns for adaptive particle therapy (APT) to evaluate current clinical practice and wishes and barriers to further implementation.
MATERIALS AND METHODS
An institutional questionnaire was distributed to PT centres worldwide (7/2020-6/2021) asking which type of APT was used, details of the workflow, and what the wishes and barriers to implementation were. Seventy centres from 17 countries participated. A three-round Delphi consensus analysis (10/2022) among the authors followed to define recommendations on required actions and future vision.
RESULTS
Out of the 68 clinically operational centres, 84% were users of APT for at least one treatment site with head and neck being most common. APT was mostly performed offline with only two online APT users (plan-library). No centre used online daily re-planning. Daily 3D imaging was used for APT by 19% of users. Sixty-eight percent of users had plans to increase their use or change their technique for APT. The main barrier was "lack of integrated and efficient workflows". Automation and speed, reliable dose deformation for dose accumulation and higher quality of in-room volumetric imaging were identified as the most urgent task for clinical implementation of online daily APT.
CONCLUSION
Offline APT was implemented by the majority of PT centres. Joint efforts between industry research and clinics are needed to translate innovations into efficient and clinically feasible workflows for broad-scale implementation of online APT.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology > Medical Radiation Physics |
UniBE Contributor: |
Bertholet, Jenny |
Subjects: |
500 Science > 530 Physics 600 Technology > 610 Medicine & health |
ISSN: |
2405-6316 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
19 May 2023 13:28 |
Last Modified: |
21 May 2023 02:26 |
Publisher DOI: |
10.1016/j.phro.2023.100442 |
PubMed ID: |
37197154 |
Uncontrolled Keywords: |
Adaptive radiotherapy (ART) Adaptive treatment planning Image guided particle therapy Interfraction anatomical variation Particle/proton therapy |
BORIS DOI: |
10.48350/182671 |
URI: |
https://boris.unibe.ch/id/eprint/182671 |
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