Schwenke, Johannes M; Thorball, Christian W; Schöpf, Isabella C; Ryom, Lene; Hasse, Barbara; Lamy, Olivier; Calmy, Alexandra; Wandeler, Gilles; Marzolini, Catia; Kahlert, Christian R; Bernasconi, Enos; Kouyos, Roger; Günthard, Huldrych F; Ledergerber, Bruno; Fellay, Jacques; Burkhalter, Felix; Tarr, Philip E (2023). Association of a Polygenic Risk Score with Osteoporosis in People Living with HIV: The Swiss HIV Cohort Study. The journal of infectious diseases, 228(6), pp. 742-750. Oxford University Press 10.1093/infdis/jiad179
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BACKGROUND
Bone mineral density (BMD) loss may be accelerated in people with HIV (PLWH). It is unknown whether an individual polygenic risk score (PRS) is associated with low BMD in PLWH.
METHODS
We included Swiss HIV Cohort Study participants of self-reported European descent, each with >2 per-protocol Dual X-ray Absorptiometry (DXA) measurements >2 years apart (2011-2020). We obtained uni-/multivariable odds ratios (OR) for DXA-defined osteoporosis based on traditional and HIV-related osteoporosis risk factors and a genome-wide PRS built from 9413 single nucleotide polymorphisms associated with low BMD in the general population. Controls were free from osteoporosis/osteopenia on all DXA measurements.
RESULTS
We included 438 participants (149 with osteoporosis, 289 controls; median age, 53 years, 82% male, 95% with suppressed HIV RNA). Participants with unfavorable osteoporosis-PRS (top vs. bottom PRS quintile) had univariable and multivariable-adjusted osteoporosis OR=4.76 (95% confidence interval [CI], 2.34-9.67) and 4.13 (1.86-9.18), respectively. For comparison, hepatitis C seropositivity, 5-year tenofovir disoproxil fumarate exposure, and parent history of hip fracture had univariable osteoporosis-OR=2.26 (1.37-3.74), 1.84 (1.40-2.43), and 1.54 (0.82-2.9), respectively.
CONCLUSIONS
In PLWH in Switzerland, osteoporosis was independently associated with a BMD-associated PRS, after adjustment for established osteoporosis risk factors including exposure to tenofovir DF.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Schöpf, Isabella Christina |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1537-6613 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
25 May 2023 14:54 |
Last Modified: |
16 Sep 2023 00:13 |
Publisher DOI: |
10.1093/infdis/jiad179 |
PubMed ID: |
37225667 |
Uncontrolled Keywords: |
HIV infection aging low bone mineral density multivariable analysis osteoporosis polygenic risk score |
BORIS DOI: |
10.48350/182892 |
URI: |
https://boris.unibe.ch/id/eprint/182892 |
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