Alwan, Heba; Ware, Julia; Boughton, Charlotte K; Wilinska, Malgorzata; Allen, Janet M; Lakshman, Rama; Nwokolo, Munachiso; Hartnell, Sara; Bally, Lia; de Beaufort, Carine; Besser, Rachel Elizabeth Jane; Campbell, Fiona; Davis, Nikki; Denver, Louise; Evants, Mark L; Fröhlich-Reiterer, Elke; Ghatak, Atrayee; Hofer, Sabine E; Kapellen, Thomas M; Leelarathna, Lalantha; ... (2023). Time spent in hypoglycemia according to age and time-of-day: Observations during closed-loop insulin delivery. Diabetes technology & therapeutics, 25(7), pp. 485-491. Mary Ann Liebert 10.1089/dia.2023.0061
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OBJECTIVE
We aimed to assess whether percentage of time spent in hypoglycemia during closed-loop insulin delivery differs by age-group and time-of-day.
METHODS
We retrospectively analyzed data from hybrid closed-loop studies involving young children (2-7 years), children and adolescents (8-18 years), adults (19-59 years), and older adults (≥60 years) with type 1 diabetes. Main outcome was time spent in hypoglycemia <3.9mmol/l. Eight weeks of data for 88 participants were analyzed.
RESULTS
Median time spent in hypoglycemia over the 24-hour period was highest in children and adolescents (4.4%; [IQR 2.4-5.0]) and very young children (4.0% [3.4-5.2]), followed by adults (2.7% [1.7-4.0]), and older adults (1.8% [1.2-2.2]); p<0.001 for difference between age-groups. Time spent in hypoglycemia during nighttime (midnight-05:59) was lower than during daytime (06:00-23:59) across all age-groups.
CONCLUSION
Time in hypoglycemia was highest in the pediatric age-group during closed-loop insulin delivery. Hypoglycemia burden was lowest overnight across all age-groups.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition 04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM) |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Al-Alwan, Heba, Bally, Lia Claudia |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1520-9156 |
Publisher: |
Mary Ann Liebert |
Funders: |
[4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
26 May 2023 09:37 |
Last Modified: |
20 Jul 2023 08:17 |
Publisher DOI: |
10.1089/dia.2023.0061 |
PubMed ID: |
37229591 |
BORIS DOI: |
10.48350/182929 |
URI: |
https://boris.unibe.ch/id/eprint/182929 |
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