TRIM29 acts as a potential senescence suppressor with epigenetic activation in nasopharyngeal carcinoma.

Yue, Caifeng; Qian, Yuanmin; Wang, Chang; Chen, Jiewei; Wang, Jing; Wang, Zifeng; Wan, Xiangbo; Cao, Sumei; Zhu, Jingde; Tao, Qian; Yan, Min; Liu, Quentin (2023). TRIM29 acts as a potential senescence suppressor with epigenetic activation in nasopharyngeal carcinoma. Cancer science, 114(8), pp. 3176-3189. Wiley 10.1111/cas.15852

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Epigenetic alterations marked by DNA methylation are frequent events during the early development of nasopharyngeal carcinoma (NPC). We identified that TRIM29 is hypomethylated and overexpressed in NPC cell lines and tissues. TRIM29 silencing not only limited the growth of NPC cells in vitro and in vivo, but also induced cellular senescence, along with reactive oxygen species (ROS) accumulation. Mechanistically, we found that TRIM29 interacted with voltage-dependent anion-selective channel 1 (VDAC1) to activate mitophagy clearing up damaged mitochondria, which are the major source of ROS. In patients with NPC, high levels of TRIM29 expression are associated with an advanced clinical stage. Moreover, we detected hypomethylation of TRIM29 in patient nasopharyngeal swab DNA. Our findings indicate that TRIM29 depends on VDAC1 to induce mitophagy and prevents cellular senescence by decreasing ROS. Detection of aberrantly methylated TRIM29 in the nasopharyngeal swab DNA could be a promising strategy for the early detection of NPC.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Wang, Chang

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1349-7006

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

31 May 2023 11:23

Last Modified:

03 Aug 2023 00:14

Publisher DOI:

10.1111/cas.15852

PubMed ID:

37248790

Uncontrolled Keywords:

ROS TRIM29 VDAC1 hypomethylation senescence

BORIS DOI:

10.48350/183026

URI:

https://boris.unibe.ch/id/eprint/183026

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