Sugar modification as a means to increase the biological performance of oligonucleotides

Leumann, Christian (2006). Sugar modification as a means to increase the biological performance of oligonucleotides. Nucleic Acids Symposium Series, 50(1), pp. 55-56. Oxford University Press 10.1093/nass/nrl167

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Modification of the ribose unit in DNA and RNA profoundly influences the self-rcognition and the biological properties of the nucleic acids. Conformational restriction of the ribose units, as in LNA and tricyclo-DNA, has been identified as a powerful tool to increase DNA and RNA affinity as well as biological stability and antisense properties. Apart from that sugar modified DNA analogues, as homo-DNA, have shown to be orthogonal base-pairing systems which by virtue of non-crosscommunicating with the natural nucleic acids open novel applications in biotechnology.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Leumann, Christian

ISSN:

0261-3166

Publisher:

Oxford University Press

Language:

English

Submitter:

Christian Leumann

Date Deposited:

04 Oct 2013 14:44

Last Modified:

10 Aug 2015 10:52

Publisher DOI:

10.1093/nass/nrl167

BORIS DOI:

10.7892/boris.18318

URI:

https://boris.unibe.ch/id/eprint/18318 (FactScience: 322)

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