Welle, Monika M (2023). Basic principles of hair follicle structure, morphogenesis, and regeneration. Veterinary pathology, 60(6), pp. 732-747. American College of Veterinary Pathologists 10.1177/03009858231176561
Full text not available from this repository. (Request a copy)Diseases affecting the hair follicle are common in domestic animals, but despite the importance of an intact skin barrier and a fully functional hair coat, knowledge about the detailed morphological features and the diversity of these complex mini-organs are often limited, although mandatory to evaluate skin biopsies with a history of alopecia. The factors that regulate the innate hair follicle formation and the postnatal hair cycle are still not completely understood in rodents, only rudimentarily known in humans, and are poorly understood in our companion animals. This review aims to summarize the current knowledge about hair follicle and hair shaft anatomy, the arrangement of hair follicles, hair follicle morphogenesis in the embryo, and the lifelong regeneration during the postnatal hair cycle in domestic animals. The role of follicular stem cells and the need for a multitude of interacting signaling events during hair follicle morphogenesis and regeneration is unquestioned. Because of the lack of state of the art methods that can be applied in rodents but are not feasible in companion animals, most of the information in this review is based on rodent studies. However, the few data from domestic animals that are available will be discussed, and it can be assumed that at least the principal molecular mechanisms are similar in rodents and other species.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) |
UniBE Contributor: |
Welle, Monika Maria |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
0300-9858 |
Publisher: |
American College of Veterinary Pathologists |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
06 Jun 2023 09:15 |
Last Modified: |
18 Oct 2023 00:12 |
Publisher DOI: |
10.1177/03009858231176561 |
PubMed ID: |
37272599 |
Uncontrolled Keywords: |
anatomy animals dog hair cycle hair follicle morphogenesis review stem cells |
URI: |
https://boris.unibe.ch/id/eprint/183190 |
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