Kettig, Eva; Kistler-Fischbacher, Melanie; de Godoi Rezende Costa Molino, Caroline; Bischoff-Ferrari, Heike A; Frundi, Devine Shimbagha (2023). Association of magnesium and vitamin D status with grip strength and fatigue in older adults: a 4-week observational study of geriatric participants undergoing rehabilitation. Aging clinical and experimental research, 35(8), pp. 1619-1629. Springer 10.1007/s40520-023-02450-7
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BACKGROUND
Low magnesium and vitamin D levels negatively affect individuals' health.
AIMS
We aimed to investigate the association of magnesium status with grip strength and fatigue scores, and evaluate whether this association differs by vitamin D status among older participants undergoing geriatric rehabilitation.
METHODS
This is a 4-week observational study of participants aged ≥ 65 years undergoing rehabilitation. The outcomes were baseline grip strength and fatigue scores, and 4-week change from baseline in grip strength and fatigue scores. The exposures were baseline magnesium tertiles and achieved magnesium tertiles at week 4. Pre-defined subgroup analyses by vitamin D status (25[OH]D < 50 nmol/l = deficient) were performed.
RESULTS
At baseline, participants (N = 253, mean age 75.7 years, 49.4% women) in the first magnesium tertile had lower mean grip strength compared to participants in the third tertile (25.99 [95% CI 24.28-27.70] vs. 30.1 [95% CI 28.26-31.69] kg). Similar results were observed among vitamin D sufficient participants (25.54 [95% CI 22.65-28.43] kg in the first magnesium tertile vs. 30.91 [27.97-33.86] kg in the third tertile). This association was not significant among vitamin D deficient participants. At week 4, no significant associations were observed between achieved magnesium tertiles and change in grip strength, overall and by vitamin D status. For fatigue, no significant associations were observed.
CONCLUSIONS
Among older participants undergoing rehabilitation, magnesium status may be relevant for grip strength, particularly among vitamin D sufficient individuals. Magnesium status was not associated with fatigue, regardless of vitamin D status.
STUDY REGISTRATION
Clinicaltrials.gov, NCT03422263; registered February 5, 2018.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM) |
UniBE Contributor: |
Frundi, Devine Shimbagha |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1720-8319 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
08 Jun 2023 11:13 |
Last Modified: |
25 Jul 2023 08:09 |
Publisher DOI: |
10.1007/s40520-023-02450-7 |
PubMed ID: |
37285075 |
Additional Information: |
Open access funding provided by University of Zurich. |
Uncontrolled Keywords: |
Fatigue Geriatric Grip strength Magnesium Rehabilitation Vitamin D |
BORIS DOI: |
10.48350/183237 |
URI: |
https://boris.unibe.ch/id/eprint/183237 |
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