Harrell, Carl Randall; Djonov, Valentin; Volarevic, Vladislav (2023). Mesenchymal stem cell-derived microRNAs: Friends or foes of tumor cells? Histology and histopathology, 38(12), pp. 1373-1379. Universidad de Murcia 10.14670/HH-18-633
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Mesenchymal stem cell (MSC)-dependent biological effects in the tumor microenvironment mainly rely on the activity of MSC-sourced microRNAs (MSC-miRNAs) which modulate protein synthesis in target tumor cells, endothelial cells and tumor-infiltrated immune cells, regulating their phenotype and function. Several MSC-sourced miRNAs (miR-221, miR-23b, miR-21-5p, miR-222/223, miR-15a miR-424, miR-30b, miR-30c) possess tumor-promoting properties and are able to enhance viability, invasiveness and metastatic potential of malignant cells, induce proliferation and sprouting of tumor endothelial cells and suppress effector functions of cytotoxic tumor-infiltrated immune cells, crucially contributing to the rapid growth and progression of tumor tissue. On the contrary, MSCs also produce "anti-tumorigenic" miRNAs (miR-100, miR-222-3p, miR-146b miR-302a, miR-338-5p, miR-100-5p and miR-1246) which suppress tumor growth and progression by: Up-regulating expression of chemoresistance-related genes in tumor cells, by suppressing neo-angiogenesis and by inducing generation of tumorotoxic phenotypes in tumor-infiltrated lymphocytes. In this review article, we summarize the current knowledge about molecular mechanisms that are responsible for MSC-miRNA-dependent alterations of intracellular signaling in tumor and immune cells and we discuss different insights regarding the therapeutic potential of MSC-derived miRNAs in cancer treatment.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy |
UniBE Contributor: |
Djonov, Valentin Georgiev |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1699-5848 |
Publisher: |
Universidad de Murcia |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 Jun 2023 09:21 |
Last Modified: |
12 Dec 2023 00:12 |
Publisher DOI: |
10.14670/HH-18-633 |
PubMed ID: |
37306386 |
BORIS DOI: |
10.48350/183361 |
URI: |
https://boris.unibe.ch/id/eprint/183361 |
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