Defining Strategies of Modulation of Antiplatelet Therapy in Patients With Coronary Artery Disease: A Consensus Document from the Academic Research Consortium.

Capodanno, Davide; Mehran, Roxana; Krucoff, Mitchell W; Baber, Usman; Bhatt, Deepak L; Capranzano, Piera; Collet, Jean-Philippe; Cuisset, Thomas; De Luca, Giuseppe; De Luca, Leonardo; Farb, Andrew; Franchi, Francesco; Gibson, C Michael; Hahn, Joo-Yong; Hong, Myeong-Ki; James, Stefan; Kastrati, Adnan; Kimura, Takeshi; Lemos, Pedro A; Lopes, Renato D; ... (2023). Defining Strategies of Modulation of Antiplatelet Therapy in Patients With Coronary Artery Disease: A Consensus Document from the Academic Research Consortium. Circulation, 147(25), pp. 1933-1944. American Heart Association 10.1161/CIRCULATIONAHA.123.064473

[img] Text
CIRCULATIONAHA.123.064473.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (928kB)

Antiplatelet therapy is the mainstay of pharmacologic treatment to prevent thrombotic or ischemic events in patients with coronary artery disease treated with percutaneous coronary intervention and those treated medically for an acute coronary syndrome. The use of antiplatelet therapy comes at the expense of an increased risk of bleeding complications. Defining the optimal intensity of platelet inhibition according to the clinical presentation of atherosclerotic cardiovascular disease and individual patient factors is a clinical challenge. Modulation of antiplatelet therapy is a medical action that is frequently performed to balance the risk of thrombotic or ischemic events and the risk of bleeding. This aim may be achieved by reducing (ie, de-escalation) or increasing (ie, escalation) the intensity of platelet inhibition by changing the type, dose, or number of antiplatelet drugs. Because de-escalation or escalation can be achieved in different ways, with a number of emerging approaches, confusion arises with terminologies that are often used interchangeably. To address this issue, this Academic Research Consortium collaboration provides an overview and definitions of different strategies of antiplatelet therapy modulation for patients with coronary artery disease, including but not limited to those undergoing percutaneous coronary intervention, and consensus statements on standardized definitions.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Valgimigli, Marco, Windecker, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1524-4539

Publisher:

American Heart Association

Language:

English

Submitter:

Pubmed Import

Date Deposited:

20 Jun 2023 11:14

Last Modified:

20 Jun 2023 11:21

Publisher DOI:

10.1161/CIRCULATIONAHA.123.064473

PubMed ID:

37335828

Uncontrolled Keywords:

acute coronary syndrome coronary artery disease percutaneous coronary intervention therapeutics

BORIS DOI:

10.48350/183542

URI:

https://boris.unibe.ch/id/eprint/183542

Actions (login required)

Edit item Edit item
Provide Feedback