Dobrindt, E M; Biebl, M; Rademacher, S; Denecke, C; Andreou, A; Raakow, J; Kröll, Dino; Öllinger, R; Pratschke, J; Chopra, S S (2020). De-novo Upper Gastrointestinal Tract Cancer after Liver Transplantation: A Demographic Report. International journal of organ transplantation medicine, 11(2), pp. 71-80.
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BACKGROUND
Immunosuppression is essential after liver transplantation (LT). It, however, increases the risk for cancer.
OBJECTIVE
To evaluate the prevalence and outcome of upper gastrointestinal (GI) tract cancer in LT patients and assess the perioperative risk of surgery for the upper GI malignancies post-LT.
METHODS
2855 patients underwent LT at our clinic from 1988 to 2018. 20 patients developed upper GI cancer. Data were retrospectively extracted from our database. Analysis included patients' specific data, tumor histopathology and stage, the treatment given and survival.
RESULTS
23 patients developed upper GI malignancies (2 gastric and 18 esophageal cancers; 3 excluded), translating to a incidence of 26.4 per 100,000 population per year. All patients were male. 80% showed alcohol-induced cirrhosis before LT. Most of the tumors were diagnosed at a stage ≥III. 70% underwent surgery and 78.6% developed postoperative complications. One-year-survival was 50%. Total survival rate was 28.6% with a median follow-up of 10 months (range: 0-184).
CONCLUSION
Upper GI malignancies are more common after LT compared to the general population. Men after LT, due to alcohol-induced liver cirrhosis, are at a higher risk. Upper GI surgery after LT can be safe, but the severe risk for complications and a poor survival require strict indications.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine |
UniBE Contributor: |
Kröll, Dino |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2008-6482 |
Language: |
English |
Submitter: |
Rahel Fuhrer |
Date Deposited: |
20 Jun 2023 11:15 |
Last Modified: |
20 Jun 2023 11:15 |
PubMed ID: |
32832042 |
Uncontrolled Keywords: |
Esophageal cancer Esophagectomy Immunosuppression Squamous cell cancer |
BORIS DOI: |
10.48350/183556 |
URI: |
https://boris.unibe.ch/id/eprint/183556 |
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