Dynamic computer simulations of electrophoresis: a versatile research and teaching tool

Thormann, W; Breadmore, MC; Caslavska, J; Mosher, RA (2010). Dynamic computer simulations of electrophoresis: a versatile research and teaching tool. Electrophoresis, 31(5), pp. 726-54. Weinheim: Wiley-VCH 10.1002/elps.200900613

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Software is available, which simulates all basic electrophoretic systems, including moving boundary electrophoresis, zone electrophoresis, ITP, IEF and EKC, and their combinations under almost exactly the same conditions used in the laboratory. These dynamic models are based upon equations derived from the transport concepts such as electromigration, diffusion, electroosmosis and imposed hydrodynamic buffer flow that are applied to user-specified initial distributions of analytes and electrolytes. They are able to predict the evolution of electrolyte systems together with associated properties such as pH and conductivity profiles and are as such the most versatile tool to explore the fundamentals of electrokinetic separations and analyses. In addition to revealing the detailed mechanisms of fundamental phenomena that occur in electrophoretic separations, dynamic simulations are useful for educational purposes. This review includes a list of current high-resolution simulators, information on how a simulation is performed, simulation examples for zone electrophoresis, ITP, IEF and EKC and a comprehensive discussion of the applications and achievements.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Clinical Pharmacology and Visceral Research (discontinued)

UniBE Contributor:

Thormann, Wolfgang and Caslavsky, Jitka

ISSN:

0173-0835

Publisher:

Wiley-VCH

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

04 May 2014 23:04

Publisher DOI:

10.1002/elps.200900613

PubMed ID:

20191541

Web of Science ID:

000275696400002

URI:

https://boris.unibe.ch/id/eprint/184 (FactScience: 196732)

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