AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-kappaB signalling pathway

Fehr, Désirée; Casanova, Carlo; Liverman, Amy; Blazkova, Hana; Orth, Kim; Dobbelaere, Dirk,; Frey, Joachim; Burr, Sarah E (2006). AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-kappaB signalling pathway. Microbiology, 152(Pt 9), pp. 2809-18. Reading, UK: Society for General Microbiology 10.1099/mic.0.28889-0

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Aeromonas salmonicida subsp. salmonicida contains a functional type III secretion system that is responsible for the secretion of the ADP-ribosylating toxin AexT. In this study, the authors identified AopP as a second effector protein secreted by this system. The aopP gene was detected in both typical and atypical A. salmonicida isolates and was found to be encoded on a small plasmid of approximately 6.4 kb. Sequence analysis indicates that AopP is a member of the YopJ family of effector proteins, a group of proteins that interfere with mitogen-activated protein kinase (MAPK) and/or nuclear factor kappa B (NF-kappaB) signalling pathways. AopP inhibits the NF-kappaB pathway downstream of IkappaB kinase (IKK) activation, while a catalytically inactivated mutant, AopPC177A, does not possess this inhibitory effect. Unlike other effectors of the YopJ family, such as YopJ and VopA, AopP does not inhibit the MAPK signalling pathway.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
Graduate Schools > Graduate School for Cellular and Biomedical Sciences (GCB)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

UniBE Contributor:

Casanova, Carlo; Blazkova, Hana; Dobbelaere, Dirk,; Frey, Joachim and Burr, Sarah Ellen

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1350-0872

Publisher:

Society for General Microbiology

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:44

Last Modified:

16 Nov 2016 08:50

Publisher DOI:

10.1099/mic.0.28889-0

PubMed ID:

16946275

Web of Science ID:

000240693600030

URI:

https://boris.unibe.ch/id/eprint/18401 (FactScience: 455)

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