The strategies of the Theileria parasite: a new twist in host-pathogen interactions

Dobbelaere, Dirk,; Küenzi, P (2004). The strategies of the Theileria parasite: a new twist in host-pathogen interactions. Current opinion in immunology, 16(4), pp. 524-30. Kidlington, UK: Elsevier 10.1016/j.coi.2004.05.009

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Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-kappa B (nuclear factor kappa B) activation is accomplished by recruiting the IKK (I kappa B kinase) complex, a central regulator of NF-kappa B pathways, to the surface of the transforming schizont, where it becomes permanently activated. Constitutive activation of the PI-3K-PKB [phosphoinositide 3-kinase-(Akt) protein kinase B] pathway is likely to be indirect and is essential for continuous proliferation. Theileria-transformed T cells express a range of anti-apoptotic proteins that can be expected to provide protection against apoptosis induced by death receptors, as well as cellular control mechanisms that are mobilised to eliminate cells that entered a cycle of uncontrolled proliferation.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology

UniBE Contributor:

Dobbelaere, Dirk,

ISSN:

0952-7915

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:44

Last Modified:

30 Jul 2014 14:14

Publisher DOI:

10.1016/j.coi.2004.05.009

PubMed ID:

15245750

Web of Science ID:

000222919200021

URI:

https://boris.unibe.ch/id/eprint/18406 (FactScience: 460)

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