Hijacking of host cell IKK signalosomes by the transforming parasite Theileria

Heussler, Volker; Rottenberg, S; Schwab, R; Küenzi, P; Fernandez, PC; McKellar, S; Shiels, B; Chen, ZJ; Orth, K; Wallach, D; Dobbelaere, Dirk, (2002). Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. Science, 5595(298), pp. 1033-1036. Washington, D.C.: American Association for the Advancement of Science 10.1126/science.1075462

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Parasites have evolved a plethora of mechanisms to ensure their propagation and evade antagonistic host responses. The intracellular protozoan parasite Theileria is the only eukaryote known to induce uncontrolled host cell proliferation. Survival of Theileria-transformed leukocytes depends strictly on constitutive nuclear factor kappa B (NF-kappaB) activity. We found that this was mediated by recruitment of the multisubunit IkappaB kinase (IKK) into large, activated foci on the parasite surface. IKK signalosome assembly was specific for the transforming schizont stage of the parasite and was down-regulated upon differentiation into the nontransforming merozoite stage. Our findings provide insights into IKK activation and how pathogens subvert host-cell signaling pathways.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology
08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Heussler, Volker and Dobbelaere, Dirk,

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0036-8075

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:44

Last Modified:

05 Jul 2016 09:35

Publisher DOI:

10.1126/science.1075462

PubMed ID:

12411708

Web of Science ID:

000178932000059

BORIS DOI:

10.7892/boris.18409

URI:

https://boris.unibe.ch/id/eprint/18409 (FactScience: 463)

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