Genome of the host-cell transforming parasite Theileria annulata compared with T. parva

Pain, A; Renauld, H; Berriman, M; Murphy, L; Yeats, CA; Weir, W; Kerhornou, A; Aslett, M; Bishop, R; Bouchier, C; Cochet, M; Coulson, RM; Cronin, A; de Villiers, EP; Fraser, A; Fosker, N; Gardner, M; Goble, A; Griffiths-Jones, S; Harris, D.E.; ... (2005). Genome of the host-cell transforming parasite Theileria annulata compared with T. parva. Science, 5731(309), pp. 131-3. Washington, D.C.: American Association for the Advancement of Science 10.1126/science.1110418

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Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology

UniBE Contributor:

Dobbelaere, Dirk,

ISSN:

0036-8075

Publisher:

American Association for the Advancement of Science

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:44

Last Modified:

17 Jul 2014 13:58

Publisher DOI:

10.1126/science.1110418

PubMed ID:

15994557

Web of Science ID:

000230212800075

URI:

https://boris.unibe.ch/id/eprint/18410 (FactScience: 464)

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