Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes

Shiels, Brian; Langsley, Gordon; Weir, William; Pain, Arnab; McKellar, Sue; Dobbelaere, Dirk, (2006). Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes. International journal for parasitology, 36(1), pp. 9-21. Kidlington, UK: Elsevier 10.1016/j.ijpara.2005.09.002

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The apicomplexan parasites Theileria annulata and Theileria parva cause severe lymphoproliferative disorders in cattle. Disease pathogenesis is linked to the ability of the parasite to transform the infected host cell (leukocyte) and induce uncontrolled proliferation. It is known that transformation involves parasite dependent perturbation of leukocyte signal transduction pathways that regulate apoptosis, division and gene expression, and there is evidence for the translocation of Theileria DNA binding proteins to the host cell nucleus. However, the parasite factors responsible for the inhibition of host cell apoptosis, or induction of host cell proliferation are unknown. The recent derivation of the complete genome sequence for both T. annulata and T. parva has provided a wealth of information that can be searched to identify molecules with the potential to subvert host cell regulatory pathways. This review summarizes current knowledge of the mechanisms used by Theileria parasites to transform the host cell, and highlights recent work that has mined the Theileria genomes to identify candidate manipulators of host cell phenotype.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology

UniBE Contributor:

Dobbelaere, Dirk,

ISSN:

0020-7519

Publisher:

Elsevier

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:44

Last Modified:

10 Jul 2014 14:54

Publisher DOI:

10.1016/j.ijpara.2005.09.002

PubMed ID:

16221473

Web of Science ID:

000235018200002

URI:

https://boris.unibe.ch/id/eprint/18411 (FactScience: 465)

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