Determinants of Treatment Toxicity in Patients with Soft Tissue Sarcomas.

Schönenberger, Katja A; Reber, Emilie; Schläppi, Karin; Baumgartner, Annic; Stanga, Zeno; Kollár, Attila (2023). Determinants of Treatment Toxicity in Patients with Soft Tissue Sarcomas. Nutrition and cancer - an international journal, 75(8), pp. 1638-1645. Routledge 10.1080/01635581.2023.2227405

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Soft tissue sarcomas are rare malignant tumors. Traditionally, treatment is guided by patient and tumor characteristics. Data on the influence of patient characteristics, particularly nutritional status, on clinical outcomes are scarce. Body composition and its changes during treatment play an essential role in predicting toxicity, clinical outcomes, and mortality. This analysis aimed to investigate the relationship between treatment toxicity and body composition. Patients diagnosed with sarcoma who underwent first-line palliative chemotherapy between October 2017 and January 2020 were included. Baseline and follow-up computed tomographic scans at the third lumbar vertebra, available from diagnostic purposes, were analyzed using SliceOmatic software. Treatment toxicity was defined as a composite score of the Common Terminology Criteria for Adverse Events. Nutritional Risk Screening (NRS) 2002 score, psoas muscle thickness to height ratio, and comorbidity showed a significant association with overall toxicity, while skeletal muscle index and age showed a strong trend. In summary, the NRS 2002 tool must be routinely implemented in inpatient and outpatient settings for cancer patients, and nutritional therapy needs to become a fixed component of multimodal cancer treatment. Furthermore, validated standardized procedures for the quantification of muscle mass are needed to individualize and optimize cancer treatment.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
UniBE Contributor:	Reber, Emilie, Schläppi, Karin, Baumgartner, Annic Catherine, Stanga, Zeno, Kollár, Attila
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0163-5581
Publisher:	Routledge
Language:	English
Submitter:	Pubmed Import
Date Deposited:	27 Jun 2023 10:15
Last Modified:	01 Aug 2023 00:15
Publisher DOI:	10.1080/01635581.2023.2227405
PubMed ID:	37358229
URI:	https://boris.unibe.ch/id/eprint/184162