Panagopoulos, Nikolaos; Grapatsas, Konstantinos; Leivaditis, Vasileios; Galanis, Michail; Dougenis, Dimitrios (2023). Are Extensive Open Lung Resections for Elderly Patients with Lung Cancer Justified? Current oncology, 30(6), pp. 5470-5484. MDPI 10.3390/curroncol30060414
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BACKGROUND
Older patients with malignancies are more comorbid than younger ones and are usually undertreated only because of their age. The aim of this study is to investigate the safety of open anatomical lung resections for lung cancer in elderly patients.
METHODS
We retrospectively analyzed all patients who underwent lung resection for lung cancer in our institution and categorized them into two groups: the elderly group (≥70 years old) and the control (<70).
RESULTS
In total, 135 patients were included in the elderly group and 375 in the control. Elderly patients were more frequently diagnosed with squamous cell carcinoma (59.3% vs. 51.5%, p = 0.037), higher differentiated tumors (12.6% vs. 6.4%, p = 0.014), and at an earlier stage (stage I: 55.6% for elderly vs. 36.6%, p = 0.002). Elderly patients were more vulnerable to postoperative pneumonia (3.7% vs. 0.8%, p = 0.034), lung atelectasis (7.4% vs. 2.9%, p = 0.040), and pleural empyema (3.2% vs. 0%, p = 0.042), however, with no increased 30-day-mortality (5.2% for elderly vs. 2.7%, p = 0.168). Survival was comparable in both groups (43.4 vs. 45.3 months, p = 0.579).
CONCLUSIONS
Elderly patients should not be excluded from open major lung resections as the survival benefit is not reduced in selected patients.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Thoracic Surgery |
UniBE Contributor: |
Galanis, Michail |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1718-7729 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
28 Jun 2023 10:29 |
Last Modified: |
29 Jun 2023 13:46 |
Publisher DOI: |
10.3390/curroncol30060414 |
PubMed ID: |
37366897 |
Uncontrolled Keywords: |
anatomical lung resection elderly lobectomy lung cancer non-small cell lung cancer pneumonectomy thoracotomy |
BORIS DOI: |
10.48350/184191 |
URI: |
https://boris.unibe.ch/id/eprint/184191 |
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