Shang, Xiao; Reche, Jelena; Lincke, Joel-Benjamin; Häner, Nathanael Urs; Lever, Mael; Böhm, Michael Rr; Bormann, Caroline; Zinkernagel, Martin S; Unterlauft, Jan Darius (2023). Stage Specific Glaucomatous Changes of the Macula recorded using Spectral Domain Optical Coherence Tomography. Photodiagnosis and photodynamic therapy, 43(103673), p. 103673. Elsevier 10.1016/j.pdpdt.2023.103673
|
Text
1-s2.0-S1572100023004003-main.pdf - Accepted Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
BACKGROUND
This study aimed to compare the thickness of different macular retinal layers in glaucomatous eyes and healthy controls, and evaluate the diagnostic performance of spectral domain optical coherence tomography (SD-OCT) parameters.
METHODS
In this cross-sectional comparative study, 48 glaucomatous eyes and 44 healthy controls were included. The thickness of the total retina and all retinal layers were obtained using the Early Treatment Diagnostic Retinopathy Study (ETDRS) grid. The minimal and average values of outer and inner ETDRS-rings were calculated. The diagnostic performance for detection of glaucoma was evaluated using the area under the receiver operating characteristic curve (AUC).
RESULTS
The thickness of the total retina, ganglion cell layer (GCL), and inner-plexiform layer (IPL) was significantly thinner in glaucomatous eyes in all sectors except the center (all p<0.05). The thickness of retinal nerve fiber layer (RNFL) was significantly thinner in the glaucoma group except in the center, nasal inner, and temporal outer sectors (all p<0.05). Layer thinning advanced with glaucoma severity. The minimal outer GCL thickness showed the highest AUC value for discrimination between glaucomatous eyes and healthy controls(0.955). The minimal outer IPL showed the highest AUC value for discriminating early-stage glaucomatous eyes from healthy controls (0.938).
CONCLUSIONS
Glaucomatous eyes were found to have significant thinning in the macular region. GCL and IPL showed high ability to discriminate glaucomatous and early-stage glaucomatous eyes from controls. Applying the minimal value to the ETDRS grid has the potential to provide good diagnostic abilities in glaucoma screening.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Reche, Jelena, Lincke, Joel-Benjamin, Häner, Nathanael, Zinkernagel, Martin Sebastian, Unterlauft, Jan Darius |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1873-1597 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
30 Jun 2023 15:41 |
Last Modified: |
08 Sep 2023 00:14 |
Publisher DOI: |
10.1016/j.pdpdt.2023.103673 |
PubMed ID: |
37380114 |
Uncontrolled Keywords: |
glaucoma macula optical coherence tomography retinal segmentation |
BORIS DOI: |
10.48350/184232 |
URI: |
https://boris.unibe.ch/id/eprint/184232 |
Actions (login required)
 |
Edit item |