The role of neuroinflammation in canine epilepsy.

von Rüden, Eva-Lotta; Potschka, Heidrun; Tipold, Andrea; Stein, Veronika Maria (2023). The role of neuroinflammation in canine epilepsy. The veterinary journal, 298-299, p. 106014. Elsevier 10.1016/j.tvjl.2023.106014

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The lack of therapeutics that prevent the development of epilepsy, improve disease prognosis or overcome drug resistance represents an unmet clinical need in veterinary as well as in human medicine. Over the past decade, experimental studies and studies in human epilepsy patients have demonstrated that neuroinflammatory processes are involved in epilepsy development and play a key role in neuronal hyperexcitability that underlies seizure generation. Targeting neuroinflammatory signaling pathways may provide a basis for clinically relevant disease-modification strategies in general, and moreover, could open up new therapeutic avenues for human and veterinary patients with drug-resistant epilepsy. A sound understanding of the neuroinflammatory mechanisms underlying seizure pathogenesis in canine patients is therefore essential for mechanism-based discovery of selective epilepsy therapies that may enable the development of new disease-modifying treatments. In particular, subgroups of canine patients in urgent needs, e.g. dogs with drug-resistant epilepsy, might benefit from more intensive research in this area. Moreover, canine epilepsy shares remarkable similarities in etiology, disease manifestation, and disease progression with human epilepsy. Thus, canine epilepsy is discussed as a translational model for the human disease and epileptic dogs could provide a complementary species for the evaluation of antiepileptic and antiseizure drugs. This review reports key preclinical and clinical findings from experimental research and human medicine supporting the role of neuroinflammation in the pathogenesis of epilepsy. Moreover, the article provides an overview of the current state of knowledge regarding neuroinflammatory processes in canine epilepsy emphasizing the urgent need for further research in this specific field. It also highlights possible functional impact, translational potential and future perspectives of targeting specific inflammatory pathways as disease-modifying and multi-target treatment options for canine epilepsy.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)

UniBE Contributor:

Stein, Veronika Maria

Subjects:

600 Technology > 630 Agriculture

ISSN:

1532-2971

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

03 Jul 2023 10:18

Last Modified:

01 Jul 2024 00:25

Publisher DOI:

10.1016/j.tvjl.2023.106014

PubMed ID:

37393038

Uncontrolled Keywords:

Animal models of epilepsy Blood-brain-barrier-dysfunction Disease-modification Immunity Microglia

BORIS DOI:

10.48350/184306

URI:

https://boris.unibe.ch/id/eprint/184306

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