The MHC-haplotype influences primary, but not memory, immune responses to an immunodominant peptide containing T- and B-cell epitopes of the caprine arthritis encephalitis virus Gag protein

Fluri, Alexandra; Nenci, Chiara; Zahno, Marie-Luise; Vogt, Hans-Rudolf; Charan, Shiv; Busato, André; Pancino, Gianfranco; Peterhans, Ernst; Obexer-Ruff, Gaby; Bertoni, Giuseppe (2006). The MHC-haplotype influences primary, but not memory, immune responses to an immunodominant peptide containing T- and B-cell epitopes of the caprine arthritis encephalitis virus Gag protein. Vaccine, 24(5), pp. 597-606. Amsterdam: Elsevier 10.1016/j.vaccine.2005.08.043

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In this report, we describe a short peptide, containing a T helper- and a B-cell epitope, located in the Gag protein of the caprine arthritis encephalitis virus (CAEV). This T-cell epitope is capable of inducing a robust T-cell proliferative response in vaccinated goats with different genetic backgrounds and to provide help for a strong antibody response to the B-cell epitope, indicating that it may function as a universal antigen-carrier for goat vaccines. The primary immune response of goats homozygous for MHC class I and II genes showed an MHC-dependent partitioning in rapid-high and slow-low responses, whereas the memory immune response was strong in both groups, demonstrating that a vaccine based on this immunodominant T helper epitope is capable to overcome genetic differences.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
UniBE Contributor:	Nenci, Chiara, Zahno, Marie-Luise, Vogt, Hans-Rudolf, Busato, André, Peterhans, Ernst, Obexer, Gaby, Bertoni, Giuseppe
ISSN:	0264-410X
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:45
Last Modified:	05 Dec 2022 14:13
Publisher DOI:	10.1016/j.vaccine.2005.08.043
PubMed ID:	16154240
Web of Science ID:	000235273900007
URI:	https://boris.unibe.ch/id/eprint/18435 (FactScience: 516)