Fluri, Alexandra; Nenci, Chiara; Zahno, Marie-Luise; Vogt, Hans-Rudolf; Charan, Shiv; Busato, André; Pancino, Gianfranco; Peterhans, Ernst; Obexer-Ruff, Gaby; Bertoni, Giuseppe (2006). The MHC-haplotype influences primary, but not memory, immune responses to an immunodominant peptide containing T- and B-cell epitopes of the caprine arthritis encephalitis virus Gag protein. Vaccine, 24(5), pp. 597-606. Amsterdam: Elsevier 10.1016/j.vaccine.2005.08.043
Full text not available from this repository. (Request a copy)In this report, we describe a short peptide, containing a T helper- and a B-cell epitope, located in the Gag protein of the caprine arthritis encephalitis virus (CAEV). This T-cell epitope is capable of inducing a robust T-cell proliferative response in vaccinated goats with different genetic backgrounds and to provide help for a strong antibody response to the B-cell epitope, indicating that it may function as a universal antigen-carrier for goat vaccines. The primary immune response of goats homozygous for MHC class I and II genes showed an MHC-dependent partitioning in rapid-high and slow-low responses, whereas the memory immune response was strong in both groups, demonstrating that a vaccine based on this immunodominant T helper epitope is capable to overcome genetic differences.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics |
UniBE Contributor: |
Nenci, Chiara, Zahno, Marie-Luise, Vogt, Hans-Rudolf, Busato, André, Peterhans, Ernst, Obexer, Gaby, Bertoni, Giuseppe |
ISSN: |
0264-410X |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:45 |
Last Modified: |
05 Dec 2022 14:13 |
Publisher DOI: |
10.1016/j.vaccine.2005.08.043 |
PubMed ID: |
16154240 |
Web of Science ID: |
000235273900007 |
URI: |
https://boris.unibe.ch/id/eprint/18435 (FactScience: 516) |
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