Forte, Paolo; Ferro Desideri, Lorenzo; Manocchio, Riccardo; Corazza, Paolo; Traverso, Carlo Enrico; Nicolò, Massimo (2024). Prechoroidal Cleft Regression After Switch to Intravitreal Brolucizumab. European journal of ophthalmology, 34(1), NP123-NP126. Sage Publications 10.1177/11206721231185903
Full text not available from this repository. (Request a copy)INTRODUCTION
Prechoroidal cleft has been described as a negative prognostic biomarker in patients affected with neovascular age related macular degeneration (nAMD). This peculiar finding consists of a lenticular hyporeflective space located between an outward bowing of Bruch's membrane and the base of a fibrovascular retinal pigment epithelium detachment (PED). Previous studies have reported the partial or complete regression of prechoroidal clefts after treatment with anti-vascular endothelial growth factor (VEGF) injections.
CASE REPORT
To report a case of complete anatomical regression of an unresponsive prechoroidal cleft after switching to intravitreal Brolucizumab. The patient maintained cleft regression over time and no adverse events (i.e., RPE tears, intraocular inflammation) were observed during follow-up.
CONCLUSIONS AND IMPORTANCE
To our knowledge, this case report is the first to analyze the clinical efficacy of brolucizumab targeting prechoroidal clefts. Clinical implication and pathogenesis of prechoroidal clefts are yet to be fully elucidated.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Ferro Desideri, Lorenzo |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1724-6016 |
Publisher: |
Sage Publications |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
10 Jul 2023 12:08 |
Last Modified: |
03 Jan 2024 00:12 |
Publisher DOI: |
10.1177/11206721231185903 |
PubMed ID: |
37415410 |
Uncontrolled Keywords: |
Brolucizumab OCT biomarker cleft neovascular age-Related macular degeneration prechoroidal cleft |
URI: |
https://boris.unibe.ch/id/eprint/184590 |
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