Sindaco, Paola; Pandey, Hritisha; Isabelle, Colleen; Chakravarti, Nitin; Brammer, Jonathan Edward; Porcu, Pierluigi; Mishra, Anjali (2023). The role of interleukin-15 in the development and treatment of hematological malignancies. Frontiers in immunology, 14, p. 1141208. Frontiers Research Foundation 10.3389/fimmu.2023.1141208
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Cytokines are a vital component of the immune system that controls the activation and growth of blood cells. However, chronic overexpression of cytokines can trigger cellular events leading to malignant transformation. The cytokine interleukin-15 (IL-15) is of particular interest, which has been shown to contribute to the development and progression of various hematological malignancies. This review will provide an overview of the impact of the immunopathogenic function of IL-15 by studying its role in cell survival, proliferation, inflammation, and treatment resistance. We will also review therapeutic approaches for inhibiting IL-15 in blood cancers.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory |
UniBE Contributor: |
Sindaco, Paola |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1664-3224 |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Pierrette Durand Lüthi |
Date Deposited: |
10 Jul 2023 10:39 |
Last Modified: |
16 Jul 2023 02:27 |
Publisher DOI: |
10.3389/fimmu.2023.1141208 |
PubMed ID: |
37153603 |
Uncontrolled Keywords: |
IL-15 blood cancer cytokine treatment |
BORIS DOI: |
10.48350/184620 |
URI: |
https://boris.unibe.ch/id/eprint/184620 |
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