Genetic analysis of syndactyly in German Holstein cattle

Drögemüller, Cord; Distl, Ottmar (2006). Genetic analysis of syndactyly in German Holstein cattle. Veterinary journal, 171(1), pp. 120-5. Amsterdam: Elsevier 10.1016/j.tvjl.2004.09.009

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Congenital syndactyly with a variable number of affected feet was observed in eight black and white German Holstein calves. Analysis of the pedigree data revealed that all affected individuals could be traced back to a single founder. The pedigree was consistent with monogenic autosomal recessive inheritance and variable expressivity. Bovine syndactyly or "mulefoot" has been previously shown to map on the telomeric end of bovine chromosome 15 and we performed PCR genotyping of microsatellite markers spanning 27 cM of this chromosomal region to test the new cases for genetic linkage with the phenotype. The haplotype segregation confirmed the suggested inheritance pattern of the mulefoot mutation in this family and markers RM004, BM848 and BMS820 showed significant linkage to the phenotype. The results confirmed the chromosomal location of the mulefoot gene in this pedigree. Furthermore the study demonstrated that although marker testing has been available for nearly a decade the use of mulefoot carriers in cattle breeding remains uncontrolled. The presented family provides a resource for positional cloning of the causative mutation.

Item Type:

Journal Article (Further Contribution)


05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics

UniBE Contributor:

Drögemüller, Cord








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Date Deposited:

04 Oct 2013 14:45

Last Modified:

04 May 2014 23:13

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URI: (FactScience: 621)

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