Telser, Julia; Grossmann, Kirsten; Weideli, Ornella C; Hillmann, Dorothea; Aeschbacher, Stefanie; Wohlwend, Niklas; Velez, Laura; Kuhle, Jens; Maleska, Aleksandra; Benkert, Pascal; Risch, Corina; Conen, David; Risch, Martin; Risch, Lorenz (2023). Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID-Results from the Prospective Population-Based COVI-GAPP Study. Diagnostics, 13(13) MDPI 10.3390/diagnostics13132167
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It is unknown whether neurological symptoms are associated with brain injury after SARS-CoV-2 infections and whether brain injury and related symptoms also emerge in Long-COVID patients. Biomarkers such as serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) can be used to elucidate neuro-axonal and astroglial injuries. We investigated whether these biomarkers are associated with COVID-19 infection status, associated symptoms and Long-COVID. From 146 individuals of the general population with a post-acute, mild-to-moderate SARS-CoV-2 infection, sNfL and sGFAP were measured before, during and after (five and ten months) the infection. Individual symptoms and Long-COVID status were assessed using questionnaires. Neurological associated symptoms were described for individuals after a mild and moderate COVID-19 infection; however, sNfL (p = 0.74) and sGFAP (p = 0.24) did not change and were not associated with headache (p = 0.51), fatigue (p = 0.93), anosmia (p = 0.77) or ageusia (p = 0.47). In Long-COVID patients, sGFAP (p = 0.038), but not sNfL (p = 0.58), significantly increased but was not associated with neurological associated symptoms. Long-COVID status, but not post-acute SARS-CoV-2 infections, may be associated with astroglial injury/activation, even if neurological associated symptoms were not correlated.
Item Type: |
Journal Article (Original Article) |
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Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2075-4418 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
17 Jul 2023 13:13 |
Last Modified: |
18 Jul 2023 09:48 |
Publisher DOI: |
10.3390/diagnostics13132167 |
PubMed ID: |
37443561 |
Uncontrolled Keywords: |
COVID-19 GFAP NfL SARS-CoV-2 glial fibrillary acidic protein neurofilament light chain serum biomarker |
BORIS DOI: |
10.48350/184853 |
URI: |
https://boris.unibe.ch/id/eprint/184853 |
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