Repetitive TMS over the human oculomotor cortex: comparison of 1-Hz and theta burst stimulation

Nyffeler, Thomas; Wurtz, Pascal; Lüscher, Hans-Rudolf; Hess, Christian W; Senn, Walter; Pflugshaupt, Tobias; von Wartburg, Roman; Lüthi, Mathias; Müri, René M (2006). Repetitive TMS over the human oculomotor cortex: comparison of 1-Hz and theta burst stimulation. Neuroscience letters, 409(1), pp. 57-60. Amsterdam: Elsevier 10.1016/j.neulet.2006.09.011

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The aim of the study was to compare the effect duration of two different protocols of repetitive transcranial magnetic stimulation (rTMS) on saccade triggering. In four experiments, two regions (right frontal eye field (FEF) and vertex) were stimulated using a 1-Hz and a theta burst protocol (three 30Hz pulses repeated at intervals of 100ms). The same number of TMS pulses (600 pulses) was applied with stimulation strength of 80% of the resting motor threshold for hand muscles. Following stimulation the subjects repeatedly performed an oculomotor task using a modified overlap paradigm, and saccade latencies were measured over a period of 60min. The results show that both 1-Hz and theta burst stimulation had inhibitory effects on saccade triggering when applied over the FEF, but not over the vertex. One-hertz rTMS significantly increased saccade latencies over a period of about 8min. After theta burst rTMS, this effect lasted up to 30min. Furthermore, the decay of rTMS effects was protocol-specific: After 1-Hz stimulation, saccade latencies returned to a baseline level much faster than after theta burst stimulation. We speculate that these time course differences represent distinct physiological mechanisms of how TMS interacts with brain function.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
UniBE Contributor:	Nyffeler, Thomas, Wurtz, Pascal, Lüscher, Hans-Rudolf, Hess, Christian Walter, Senn, Walter, Pflugshaupt, Tobias, von Wartburg, Roman, Lüthi Steinheimer, Mathias, Müri, René Martin
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0304-3940
ISBN:	17049743
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:45
Last Modified:	05 Dec 2022 14:14
Publisher DOI:	10.1016/j.neulet.2006.09.011
PubMed ID:	17049743
Web of Science ID:	000242101800012
URI:	https://boris.unibe.ch/id/eprint/18512 (FactScience: 684)