Amodeo, Antonio; Stojanovic, Milena; Erdil, Tugba; Dave, Hitendu; Cesnjevar, Robert; Paal, Sebastian; Kretschmar, Oliver; Schweiger, Martin (2023). Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation-A Ten-Year Single-Center Report. Life, 13(7) MDPI 10.3390/life13071582
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For children born with congenital heart defects (CHDs), extracorporeal life support may be necessary. This retrospective single-center study aimed to investigate the outcomes of children with CHDs on extracorporeal membrane oxygenation (ECMO), focusing on various risk factors. Among the 88 patients, 36 (41%) had a single-ventricle heart defect, while 52 (59%) had a biventricular defect. In total, 25 (28%) survived, with 7 (8%) in the first group and 18 (20%) in the latter. A p-value of 0.19 indicated no significant difference in survival rates. Children with biventricular hearts had shorter ECMO durations but longer stays in the intensive care unit. The overall rate of complications on ECMO was higher in children with a single ventricle (odds ratio [OR] 1.57, 95% confidence interval [CI] 0.67-3.7); bleeding was the most common complication in both groups. The occurrence of a second ECMO run was more frequent in patients with a single ventricle (22% vs. 9.6%). ECMO can be effective for children with congenital heart defects, including single-ventricle patients. Bleeding remains a serious complication associated with worse outcomes. Patients requiring a second ECMO run within 30 days have lower survival rates.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Thoracic Surgery |
UniBE Contributor: |
Erdil, Tugba |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2075-1729 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
02 Aug 2023 09:45 |
Last Modified: |
02 Aug 2023 09:54 |
Publisher DOI: |
10.3390/life13071582 |
PubMed ID: |
37511957 |
Uncontrolled Keywords: |
ECMO complications congenital heart disease extracorporeal life support mortality risk factors single ventricle |
BORIS DOI: |
10.48350/185128 |
URI: |
https://boris.unibe.ch/id/eprint/185128 |
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