Alberts, Ian; Seibel, Sigrid; Xue, Song; Viscione, Marco; Mingels, Clemens; Sari, Hasan; Afshar-Oromieh, Ali; Limacher, Andreas; Rominger, Axel Oliver (2023). Investigating the influence of long-axial versus short-axial field of view PET/CT on stage migration in lymphoma and non-small cell lung cancer. Nuclear medicine communications, 44(11), pp. 988-996. Lippincott Williams & Wilkins 10.1097/MNM.0000000000001745
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OBJECTIVES
The objective of this study was to evaluate the influence of a long-axial field-of-view (LAFOV) on stage migration using a large single-centre retrospective cohort in lymphoma and non-small cell lung cancer (NSCLC).
METHODS
A retrospective study is performed for patients undergoing PET/computed tomography (CT) on either a short-axial field-of-view (SAFOV) or LAFOV PET/CT system for the staging of known or suspected NSCLC or for therapeutic response in lymphoma. The primary endpoint was the Deauville therapy response score for patients with lymphoma for the two systems. Secondary endpoints were the American Joint Committee on Cancer stage for NSCLC, the frequency of cN3 and cM1 findings, the probability for a positive nodal staging (cN1-3) for NSCLC and the diagnostic accuracy for nodal staging in NSCLC.
RESULTS
One thousand two hundred eighteen records were screened and 597 patients were included for analysis (N = 367 for lymphoma and N = 291 for NSCLC). For lymphoma, no significant differences were found in the proportion of patients with complete metabolic response versus non-complete metabolic response Deauville response scores (P = 0.66). For NSCLC no significant differences were observed between the two scanners for the frequency of cN3 and cM1 findings, for positive nodal staging, neither the sensitivity nor the specificity.
CONCLUSIONS
In this study use of a LAFOV system was neither associated with upstaging in lymphoma nor NSCLC compared to a digital SAFOV system. Diagnostic accuracy was comparable between the two systems in NSCLC despite shorter acquisition times for LAFOV.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine 04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR) |
UniBE Contributor: |
Alberts, Ian Leigh, Seibel, Sigrid Elisabeth, Xue, Song, Mingels, Clemens, Afshar Oromieh, Ali, Limacher, Andreas, Rominger, Axel Oliver |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0143-3636 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
16 Aug 2023 09:30 |
Last Modified: |
20 Feb 2024 14:15 |
Publisher DOI: |
10.1097/MNM.0000000000001745 |
PubMed ID: |
37578376 |
BORIS DOI: |
10.48350/185466 |
URI: |
https://boris.unibe.ch/id/eprint/185466 |
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