Michel, Chantal; Osman, N; Rinaldi, Giulia; Schimmelmann, Benno Karl Edgar; Kindler, Jochen; Schultze-Lutter, Frauke (10 July 2023). Course of Clinical High Risk Symptoms for Psychosis in the Community: A Latent Class Analysis (Unpublished). In: IEPA's 14th International Conference on Early Intervention in Mental Health. Lausanne, Switzerland. 10.07.-12.07.2023.
Typically, studies of the longitudinal course of clinical high-risk (CHR) for psychosis symptoms have focussed on transition rates (mostly in help-seeking samples). However, more recent research considers clinical presentation over time, regardless of transition. Moreover, given the heterogeneity in clinical presentation of CHR symptoms, it is important to parse out heterogeneity in clinical profiles. Therefore, the aim of this study was to explore clinical profiles of individuals in the community presenting with CHR symptoms, and to compare them longitudinally.
Participants (N=829) comprised individuals from a community sample in Switzerland. Latent Class Analysis was applied to baseline CHR symptom data, and class profiles were characterised across demographic and clinical variables, including non-psychotic DSM-IV axis I and social and occupational functioning. We then compared these profiles with follow-up data from three years later.
The best fit was the 3-class solution (BIC=3332.746, AIC=3611.239, entropy=0.91), comprising class 1 (n=19) – persecutory ideas, perceptual abnormalities, derealisation; class 2 (n=25) – mainly unusual thought content, disorganized communication; class 3 (n=785) – least symptomatic group. Classes could also be distinguished by differences in clinical variables. Over time, all classes improved clinically in terms of functioning and Axis-1 disorders, although significant differences between classes on these variables remained. Class 1 still presented with higher comorbidity and deficits in functioning.
Findings provide a more nuanced view of CHR symptoms in the community and their associated clinical presentation and course over time. Findings can also be used to inform psychoeducation regarding the course of CHR and associated symptoms.
Item Type: |
Conference or Workshop Item (Speech) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy |
UniBE Contributor: |
Michel, Chantal, Rinaldi, Giulia, Schimmelmann, Benno Karl Edgar, Kindler, Jochen, Schultze-Lutter, Frauke |
Subjects: |
600 Technology > 610 Medicine & health |
Language: |
English |
Submitter: |
Chantal Michel |
Date Deposited: |
21 Aug 2023 11:42 |
Last Modified: |
21 Aug 2023 11:42 |
URI: |
https://boris.unibe.ch/id/eprint/185604 |
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