Merlo, Francesco; Groothof, Dion; Khatami, Farnaz; Sadat Ahanchi, Noushin; Wehrli, Faina; Bakker, Stephan J L; Eisenga, Michele F; Muka, Taulant (2023). Changes in Iron Status Biomarkers with Advancing Age According to Sex and Menopause: A Population-Based Study. Journal of clinical medicine, 12(16), p. 5338. MDPI 10.3390/jcm12165338
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BACKGROUND
The risk of chronic diseases increases markedly with age and after menopause. An increase in bodily iron following menopause could contribute to this phenomenon of increased risk of chronic diseases. We aimed to investigate how various iron biomarkers change with advancing age, according to sex and menopausal status.
METHODS
We enrolled community-dwelling individuals with available information on ferritin, transferrin, iron, hepcidin, and soluble transferrin receptor levels from the Prevention of Renal and Vascular Endstage Disease study. The association of the iron biomarkers with age, sex, and menopausal status was investigated with linear regression models.
RESULTS
Mean (SD) age of the 5222 individuals (2680 women [51.3%], among whom 907 [33.8%] were premenopausal, 529 [19.7%] perimenopausal, and 785 [29.3%] postmenopausal), was 53.4 (12.0) years. Iron biomarkers showed a constant increase in women throughout their life course, in some cases at older ages surpassing values in men who, in turn, showed consistently higher levels of iron status compared to women in most age categories. Ferritin, hepcidin, and transferrin saturation levels were 3.03, 2.92, and 1.08-fold (all p < 0.001) higher in postmenopausal women compared to premenopausal.
CONCLUSIONS
We found that iron accumulates differently depending on sex, age, and menopausal status. An increased iron status was identified in women, especially during and after menopause.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Khatami, Farnaz, Sadat Ahanchi, Noushin |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
2077-0383 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
30 Aug 2023 09:50 |
Last Modified: |
24 Sep 2023 02:29 |
Publisher DOI: |
10.3390/jcm12165338 |
PubMed ID: |
37629382 |
Additional Information: |
Merlo, Groothof, Khatami and Ahanchi contributed equally to this work (shared first authorship). |
Uncontrolled Keywords: |
age and menopausal status iron biomarkers |
BORIS DOI: |
10.48350/185768 |
URI: |
https://boris.unibe.ch/id/eprint/185768 |
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