Thwaites, Philip; Hagmann, Cornelia; Schneider, Juliane; Schulzke, Sven M; Grunt, Sebastian; Nguyen, Thi Dao; Bassler, Dirk; Natalucci, Giancarlo (2023). Trends in Outcomes of Major Intracerebral Haemorrhage in a National Cohort of Very Preterm Born Infants in Switzerland. Children, 10(8) MDPI 10.3390/children10081412
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BACKGROUND
Major brain lesions, such as grade 3 intraventricular haemorrhage (G3-IVH) and periventricular haemorrhagic infarction (PVHI) are among the main predictors for poor neurodevelopment in preterm infants. In the last decades advancements in neonatal care have led to a general decrease in adverse outcomes.
AIM
To assess trends of mortality and neurodevelopmental impairment (NDI) in a recent Swiss cohort of very preterm infants with grade 3 intraventricular haemorrhage (G3-IVH) and periventricular haemorrhagic infarction (PVHI).
METHODS
In this retrospective population-based cohort study, rates of mortality, and NDI at 2 years corrected age were reported in infants born at 24-29 weeks gestational age (GA) in Switzerland in 2002-2014, with G3-IVH and/or PVHI.
RESULTS
Out of 4956 eligible infants, 462 (9%) developed G3-IVH (n = 172) or PVHI (n = 290). The average mortality rates for the two pathologies were 33% (56/172) and 60% (175/290), respectively. In 2002-2014, no change in rates of mortality (G3-IVH, p = 0.845; PVHI, p = 0.386) or NDI in survivors (G3-IVH, p = 0.756; PVHI, p = 0.588) were observed, while mean GA decreased (G3-IVH, p = 0.020; PVHI, p = 0.004). Multivariable regression analysis showed a strong association of G3-IVH and PVHI for both mortality and NDI. Death occurred after withdrawal of care in 81% of cases.
CONCLUSION
In 2002-2014, rates of mortality and NDI in very preterm born infants with major brain lesions did not change. The significant decrease in mean GA and changing hospital policies over this time span may factor into the interpretation of these results.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics |
UniBE Contributor: |
Grunt, Sebastian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2227-9067 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
30 Aug 2023 15:56 |
Last Modified: |
11 Jan 2024 12:40 |
Publisher DOI: |
10.3390/children10081412 |
PubMed ID: |
37628411 |
Uncontrolled Keywords: |
grade 3 intraventricular haemorrhage major intraventricular haemorrhage mortality neurodevelopment outcome periventricular periventricular haemorrhagic infarction preterm infant |
BORIS DOI: |
10.48350/185772 |
URI: |
https://boris.unibe.ch/id/eprint/185772 |
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