Daamen, Marcel; Scheef, Lukas; Li, Shumei; Grothe, Michel J; Gaertner, Florian C; Buchert, Ralph; Buerger, Katharina; Dobisch, Laura; Drzezga, Alexander; Essler, Markus; Ewers, Michael; Fliessbach, Klaus; Herrera Melendez, Ana Lucia; Hetzer, Stefan; Janowitz, Daniel; Kilimann, Ingo; Krause, Bernd Joachim; Lange, Catharina; Laske, Christoph; Munk, Matthias H; ... (2023). Cortical Amyloid Burden Relates to Basal Forebrain Volume in Subjective Cognitive Decline. Journal of Alzheimer's disease, 95(3), pp. 1013-1028. IOS Press 10.3233/JAD-230141
Full text not available from this repository. (Request a copy)BACKGROUND
Atrophy of cholinergic basal forebrain (BF) nuclei is a frequent finding in magnetic resonance imaging (MRI) volumetry studies that examined patients with prodromal or clinical Alzheimer's disease (AD), but less clear for individuals in earlier stages of the clinical AD continuum.
OBJECTIVE
To examine BF volume reductions in subjective cognitive decline (SCD) participants with AD pathologic changes.
METHODS
The present study compared MRI-based BF volume measurements in age- and sex-matched samples of N = 24 amyloid-positive and N = 24 amyloid-negative SCD individuals, based on binary visual ratings of Florbetaben positron emission tomography (PET) measurements. Additionally, we assessed associations of BF volume with cortical amyloid burden, based on semiquantitative Centiloid (CL) analyses.
RESULTS
Group differences approached significance for BF total volume (p = 0.061) and the Ch4 subregion (p = 0.059) only, showing the expected relative volume reductions for the amyloid-positive subgroup. There were also significant inverse correlations between BF volumes and CL values, which again were most robust for BF total volume and the Ch4 subregion.
CONCLUSIONS
The results are consistent with the hypothesis that amyloid-positive SCD individuals, which are considered to represent a transitional stage on the clinical AD continuum, already show incipient alterations of BF integrity. The negative association with a continuous measure of cortical amyloid burden also suggests that this may reflect an incremental process. Yet, further research is needed to evaluate whether BF changes already emerge at "grey zone" levels of amyloid accumulation, before amyloidosis is reliably detected by PET visual readings.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Rominger, Axel Oliver |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1875-8908 |
Publisher: |
IOS Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
30 Aug 2023 14:23 |
Last Modified: |
03 Oct 2023 00:15 |
Publisher DOI: |
10.3233/JAD-230141 |
PubMed ID: |
37638433 |
Uncontrolled Keywords: |
Acetylcholine Alzheimer’s disease amyloid atrophy basal forebrain cognitive decline |
URI: |
https://boris.unibe.ch/id/eprint/185801 |
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