Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine

Rendi-Wagner, Pamela; Shouval, Daniel; Genton, Blaise; Lurie, Yoav; Rümke, Hans; Boland, Greet; Cerny, Andreas; Heim, Markus; Bach, Doris; Schroeder, Manfred; Kollaritsch, Herwig (2006). Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine. Vaccine, 24(15), pp. 2781-9. Amsterdam: Elsevier 10.1016/j.vaccine.2006.01.007

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Conventional hepatitis B vaccines do not elicit adequate antibody production in 5-10% vaccinees. This trial tests the ability of a third-generation vaccine, containing PreS1 and PreS2 antigens in addition to the S antigen, to elicit seroprotective titres in documented non- and low-responders, compared with those to a conventional vaccine. In the primary population of non-responders (<10 IU/l anti-HBs antibodies after > or = 4 previous injections of conventional vaccine) an enhanced antibody response was seen to additional injections of the third-generation vaccine compared with a conventional vaccine (absolute difference 14.9%; P = 0.006). Enhanced antibody responses were also found in a population that included low responders.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Clinical Pharmacology and Visceral Research [discontinued]

UniBE Contributor:

Cerny, Andreas

ISSN:

0264-410X

ISBN:

16455169

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:45

Last Modified:

17 Mar 2015 21:43

Publisher DOI:

10.1016/j.vaccine.2006.01.007

PubMed ID:

16455169

Web of Science ID:

000236931700010

URI:

https://boris.unibe.ch/id/eprint/18581 (FactScience: 774)

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