Miron, Richard J; Bohner, Marc; Zhang, Yufeng; Bosshardt, Dieter D (2024). Osteoinduction and osteoimmunology: Emerging concepts. Periodontology 2000, 94(1), pp. 9-26. Blackwell 10.1111/prd.12519
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The recognition and importance of immune cells during bone regeneration, including around bone biomaterials, has led to the development of an entire field termed "osteoimmunology," which focuses on the connection and interplay between the skeletal system and immune cells. Most studies have focused on the "osteogenic" capacity of various types of bone biomaterials, and much less focus has been placed on immune cells despite being the first cell type in contact with implantable devices. Thus, the amount of literature generated to date on this topic makes it challenging to extract needed information. This review article serves as a guide highlighting advancements made in the field of osteoimmunology emphasizing the role of the osteoimmunomodulatory properties of biomaterials and their impact on osteoinduction. First, the various immune cell types involved in bone biomaterial integration are discussed, including the prominent role of osteal macrophages (OsteoMacs) during bone regeneration. Thereafter, key biomaterial properties, including topography, wettability, surface charge, and adsorption of cytokines, growth factors, ions, and other bioactive molecules, are discussed in terms of their impact on immune responses. These findings highlight and recognize the importance of the immune system and osteoimmunology, leading to a shift in the traditional models used to understand and evaluate biomaterials for bone regeneration.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Periodontics Research 04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Miron, Richard John, Bosshardt, Dieter |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0906-6713 |
Publisher: |
Blackwell |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
04 Sep 2023 10:26 |
Last Modified: |
18 May 2024 00:12 |
Publisher DOI: |
10.1111/prd.12519 |
PubMed ID: |
37658591 |
Uncontrolled Keywords: |
OsteoMacs immune cells osteoimmunology osteoinduction osteoinductive bone grafts |
BORIS DOI: |
10.48350/186000 |
URI: |
https://boris.unibe.ch/id/eprint/186000 |
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