Schlottmann, Frederik; Strauß, Sarah; Ziesing, Stefan; Reineke, Christiane; Ipaktchi, Ramin; Weyand, Birgit; Krezdorn, Nicco; Vogt, Peter Maria; Bucan, Vesna (2024). Organization of Hannover Skin Bank: Sterile culture and procurement protocols for viable cryopreserved allogeneic skin grafts of living donors. International wound journal, 21(1), e14374. Wiley 10.1111/iwj.14374
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Preserved allogeneic donor skin still represents one of the gold standard therapies in temporary wound coverage in severely burned patients or chronic wounds. Allogeneic skin grafts are currently commercially available as cryo- or glycerol-preserved allografts through skin tissue banks all over the world. Most of the skin tissue banks rely on human cadaveric skin donations. Due to the chronic shortage of human allogeneic transplants, such as skin, and increasing costs in the procurement of allografts from other skin tissue banks, Hannover Medical School has been building up its own skin tissue bank based on allogeneic skin grafts from living donors who underwent surgical treatment (i.e., body-contouring procedures, such as abdominioplasties). This article presents procedures and protocols for the procurement and processing of allogeneic skin grafts according to national legislation and European regulations and guidelines. Beside protocols, initial microbiological data regarding the sterility of the harvested grafts are presented. The results currently form the basis for further investigations as well as clinical applications. In summary, a microbiological testing and acceptance procedure is presented that ensures adequate patient safety and skin viability.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Plastic, Reconstructive and Aesthetic Surgery 04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery |
UniBE Contributor: |
Ipaktchi, Ramin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1742-481X |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
07 Sep 2023 16:18 |
Last Modified: |
17 Apr 2024 14:01 |
Publisher DOI: |
10.1111/iwj.14374 |
PubMed ID: |
37675770 |
Uncontrolled Keywords: |
allografts skin skin transplantation tissue banks tissue donors |
BORIS DOI: |
10.48350/186134 |
URI: |
https://boris.unibe.ch/id/eprint/186134 |
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