Witthauer, Lilian; Roussakis, Emmanuel; Cascales, Juan Pedro; Goss, Avery; Li, Xiaolei; Cralley, Alexis; Yoeli, Dor; Moore, Hunter B; Wang, Zhaohui; Wang, Yong; Li, Bing; Huang, Christene A; Moore, Ernest E; Evans, Conor L (2023). Development and in-vivo validation of a portable phosphorescence lifetime-based fiber-optic oxygen sensor. Scientific reports, 13(1), p. 14782. Springer Nature 10.1038/s41598-023-41917-5
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Oxygenation is a crucial indicator of tissue viability and function. Oxygen tension ([Formula: see text]), i.e. the amount of molecular oxygen present in the tissue is a direct result of supply (perfusion) and consumption. Thus, measurement of [Formula: see text] is an effective method to monitor tissue viability. However, tissue oximetry sensors commonly used in clinical practice instead rely on measuring oxygen saturation ([Formula: see text]), largely due to the lack of reliable, affordable [Formula: see text] sensing solutions. To address this issue we present a proof-of-concept design and validation of a low-cost, lifetime-based oxygen sensing fiber. The sensor consists of readily-available off-the shelf components such as a microcontroller, a light-emitting diode (LED), an avalanche photodiode (APD), a temperature sensor, as well as a bright in-house developed porphyrin molecule. The device was calibrated using a benchtop setup and evaluated in three in vivo animal models. Our findings show that the new device design in combination with the bright porphyrin has the potential to be a useful and accurate tool for measuring [Formula: see text] in tissue, while also highlighting some of the limitations and challenges of oxygen measurements in this context.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition |
UniBE Contributor: |
Witthauer, Lilian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
12 Sep 2023 12:33 |
Last Modified: |
29 Oct 2023 02:23 |
Publisher DOI: |
10.1038/s41598-023-41917-5 |
PubMed ID: |
37679415 |
BORIS DOI: |
10.48350/186151 |
URI: |
https://boris.unibe.ch/id/eprint/186151 |
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