Pavan, Jacopo; Herzig, David; Tripyla, Afrodity; Dalla Man, Chiara; Bally, Lia; Del Favero, Simone (2023). Clinical evaluation of a decision support system for glucose infusion in hypoglycaemic clamp experiments. Diabetes, obesity & metabolism, 25(12), pp. 3709-3715. Wiley 10.1111/dom.15265
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AIM
To provide a preliminary evaluation of the accuracy and safety of Gluclas decision support system suggestions in a hypoglycaemic clamp study.
METHODS
This analysis was performed using data from 32 participants (four groups with different glucose-insulin regulation: post Roux-en-Y gastric bypass with and without postprandial hypoglycaemia syndrome, postsleeve gastrectomy and non-operated controls) undergoing Gluclas-assisted hypoglycaemic clamps (target: 2.5 mmol/L for 20 minutes at 150 minutes after oral glucose ingestion). Gluclas provided glucose infusion rate suggestions upon manual entry of blood glucose values (every 5 minutes), which were either followed or overruled by investigators after critical review. Accuracy and safety were evaluated by mean absolute error (MAE), mean absolute percentage error (MAPE), average glucose level, coefficient of variation (CV) and minimal glucose level during the 20-minute hypoglycaemic period.
RESULTS
Investigators accepted 84% of suggestions, with a mean deviation of 30.33 mg/min. During the hypoglycaemic period, the MAE was 0.16 (0.12-0.24) (median [interquartile range]) mmol/L and the MAPE was 6.12% (4.80%-9.29%). CV was 4.90% (3.58%-7.27%), with 5% considered the threshold for sufficient quality. The minimal glucose level was 2.40 (2.30-2.50) mmol/L.
CONCLUSIONS
Gluclas achieved sufficiently high accuracy with minimal safety risks in a population with differences in glucose-insulin dynamics, underscoring its applicability to various patient groups.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition |
UniBE Contributor: |
Herzig, David, Tripyla, Afroditi, Bally, Lia Claudia |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1463-1326 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Sep 2023 10:54 |
Last Modified: |
11 Nov 2023 00:14 |
Publisher DOI: |
10.1111/dom.15265 |
PubMed ID: |
37681278 |
Uncontrolled Keywords: |
bariatric surgery clinical trial glycaemic control hypoglycaemia |
BORIS DOI: |
10.48350/186177 |
URI: |
https://boris.unibe.ch/id/eprint/186177 |
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