Dimethyl Fumarate Used as an Effective Treatment for Granuloma Annulare Disseminatum: An Immunohistochemical Case Study.

Gabutti, Max; Heidemeyer, Kristine; Seyed Jafari, S Morteza; Bossart, Simon; Hunger, Robert E; Feldmeyer, Laurence; Yawalkar, Nikhil (2023). Dimethyl Fumarate Used as an Effective Treatment for Granuloma Annulare Disseminatum: An Immunohistochemical Case Study. International journal of molecular sciences, 24(17) MDPI 10.3390/ijms241713355

[img]
Preview
Text
ijms-24-13355-v2.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

This investigation demonstrates the use of dimethyl fumarate (DMF) for the treatment of disseminated granuloma annulare (GAD), a rare and chronic inflammatory skin disease. In this case, progressive GAD was treated with DMF, resulting in significant improvement of skin lesions within 5 weeks and complete healing within 7 months. Clinical response was associated with a reduction in inflammatory cells, including both T cell subsets (CD4+ > CD8+), CD183+/CXCR3+ cells, Langerhans cells (CD1a+), myeloid DCs, M1- and M2-like macrophages and the activation marker HLA-DR in immunohistochemical analysis. These findings support the use of DMF as a promising treatment option for this rare skin condition.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Gabutti, Max Philip, Heidemeyer, Kristine, Jafari, Morteza, Bossart, Simon, Hunger, Robert, Feldmeyer, Laurence, Yawalkar, Nikhil

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1422-0067

Publisher:

MDPI

Language:

English

Submitter:

Pubmed Import

Date Deposited:

11 Sep 2023 12:35

Last Modified:

28 Dec 2023 09:49

Publisher DOI:

10.3390/ijms241713355

PubMed ID:

37686161

Uncontrolled Keywords:

dimethyl fumarate granuloma annulare disseminatum inflammatory cells

BORIS DOI:

10.48350/186191

URI:

https://boris.unibe.ch/id/eprint/186191

Actions (login required)

Edit item Edit item
Provide Feedback