Gabutti, Max; Heidemeyer, Kristine; Seyed Jafari, S Morteza; Bossart, Simon; Hunger, Robert E; Feldmeyer, Laurence; Yawalkar, Nikhil (2023). Dimethyl Fumarate Used as an Effective Treatment for Granuloma Annulare Disseminatum: An Immunohistochemical Case Study. International journal of molecular sciences, 24(17) MDPI 10.3390/ijms241713355
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This investigation demonstrates the use of dimethyl fumarate (DMF) for the treatment of disseminated granuloma annulare (GAD), a rare and chronic inflammatory skin disease. In this case, progressive GAD was treated with DMF, resulting in significant improvement of skin lesions within 5 weeks and complete healing within 7 months. Clinical response was associated with a reduction in inflammatory cells, including both T cell subsets (CD4+ > CD8+), CD183+/CXCR3+ cells, Langerhans cells (CD1a+), myeloid DCs, M1- and M2-like macrophages and the activation marker HLA-DR in immunohistochemical analysis. These findings support the use of DMF as a promising treatment option for this rare skin condition.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Gabutti, Max Philip, Heidemeyer, Kristine, Jafari, Morteza, Bossart, Simon, Hunger, Robert, Feldmeyer, Laurence, Yawalkar, Nikhil |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1422-0067 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Sep 2023 12:35 |
Last Modified: |
28 Dec 2023 09:49 |
Publisher DOI: |
10.3390/ijms241713355 |
PubMed ID: |
37686161 |
Uncontrolled Keywords: |
dimethyl fumarate granuloma annulare disseminatum inflammatory cells |
BORIS DOI: |
10.48350/186191 |
URI: |
https://boris.unibe.ch/id/eprint/186191 |
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