Siklody, C Herrera; Schiappacasse, L; Jumeau, R; Reichlin, T; Saguner, A M; Andratschke, N; Elicin, O; Schreiner, F; Kovacs, B; Mayinger, M; Huber, A; Verhoeff, J J C; Pascale, P; Solana Muñoz, J; Luca, A; Domenichini, G; Moeckli, R; Bourhis, J; Ozsahin, E M and Pruvot, E (2023). Recurrences of ventricular tachycardia after stereotactic arrhythmia radioablation arise outside the treated volume: analysis of the swiss cohort. Europace, 25(10) Oxford University Press 10.1093/europace/euad268
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BACKGROUND AND AIMS
Stereotactic arrhythmia radioablation (STAR) has been recently introduced for the management of therapy-refractory ventricular tachycardia (VT). VT recurrences have been reported after STAR but the mechanisms remain largely unknown. We analyzed recurrences in our patients after STAR.
METHODS
From 09.2017 to 01.2020, 20 patients (68±8y, LVEF 37±15%) suffering from refractory VT were enrolled, 16/20 with a history of at least 1 electrical storm. Before STAR, an invasive electro-anatomical mapping (Carto3) of the VT substrate was performed. A mean dose of 23±2Gy was delivered to the planning target volume (PTV).
RESULTS
The median ablation volume was 26 ml (range 14-115) and involved the interventricular septum in 75% of patients. During the first 6 months after STAR, VT burden decreased by 92% (median value, from 108 to 10 VT/semester). After a median follow-up of 25 months, 12/20 (60%) developed a recurrence and underwent a redo ablation. VT recurrence was located in proximity of the treated substrate in 9 cases, remote from the PTV in 3 cases and involved a larger substrate over ≥3 LV segments in 2 cases. No recurrences occurred inside the PTV. Voltage measurements showed a significant decrease in both bipolar and unipolar signal amplitude after STAR.
CONCLUSION
STAR is a new tool available for the treatment of VT, allowing for a significant reduction of VT burden. VT recurrences are common during follow-up, but no recurrences were observed inside the PTV. Local efficacy was supported by a significant decrease in both bipolar and unipolar signal amplitude.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology 04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Reichlin, Tobias Roman, Eliçin, Olgun |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1532-2092 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 Sep 2023 12:58 |
Last Modified: |
06 Oct 2023 00:15 |
Publisher DOI: |
10.1093/europace/euad268 |
PubMed ID: |
37695314 |
Uncontrolled Keywords: |
Ventricular tachycardia arrhythmogenic substrate electrical storm radiofrequency catheter ablation stereotactic arrhythmia radioablation toxicity |
BORIS DOI: |
10.48350/186237 |
URI: |
https://boris.unibe.ch/id/eprint/186237 |
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