Detection and distribution of apoptotic cell death in normal and diseased canine cranial cruciate ligaments

Gyger, Odile; Botteron, Catherine; Doherr, Markus; Zurbriggen, Andreas; Schawalder, Peter; Spreng, David (2007). Detection and distribution of apoptotic cell death in normal and diseased canine cranial cruciate ligaments. Veterinary journal, 174(2), pp. 371-7. Amsterdam: Elsevier 10.1016/j.tvjl.2006.07.006

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One of the possible initiating factors in canine cranial cruciate ligament (CCL) rupture could be an abnormal pattern of ligament cell death. This study compared apoptotic cell death in sections of ruptured CCLs and normal controls, and examined nitric oxide (NO) production in joint tissues and correlated this to apoptosis. CCLs and cartilage from the lateral femoral condyle were harvested from 10 healthy dogs and 15 dogs with CCL rupture and ligaments were further processed to detect cleaved caspase-3 and to determine supernatant NO production in explant cultures. Apoptotic activity was greater in ruptured ligaments compared to controls. NO in ligaments showed a moderate but significant positive correlation with caspase-positive cells. The results suggest that increased apoptosis has a role in CCL rupture and that apoptosis may be influenced by local NO production.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DVK - Clinical Research (discontinued)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research

UniBE Contributor:

Botteron, Catherine; Doherr, Marcus; Zurbriggen, Andreas; Schawalder, Peter and Spreng, David

Subjects:

600 Technology > 630 Agriculture

ISSN:

1090-0233

Publisher:

Elsevier

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:45

Last Modified:

03 Feb 2015 10:11

Publisher DOI:

10.1016/j.tvjl.2006.07.006

PubMed ID:

16956780

Web of Science ID:

000250213100024

URI:

https://boris.unibe.ch/id/eprint/18625 (FactScience: 826)

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