Hertenstein, Elisabeth; Kuhn, Marion; Landmann, Nina; Maier, Jonathan-Gabriel; Schneider, Carlotta Louisa; Fehér, Kristoffer Daniel; Frase, Lukas; Riemann, Dieter; Feige, Bernd; Nissen, Christoph (2023). Brain-derived neurotrophic factor genetic polymorphism rs6265 and creativity. PLoS ONE, 18(9), e0291397. Public Library of Science 10.1371/journal.pone.0291397
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The protein brain-derived neurotrophic factor (BDNF) promotes neural plasticity of the central nervous system and plays an important role for learning and memory. A single nucleotide polymorphism (rs6265) at position 66 in the pro-region of the human BDNF gene, resulting in a substitution of the amino acid valine (val) with methionine (met), leads to attenuated BDNF secretion and has been associated with reduced neurocognitive function. Inhomogeneous results have been found regarding the effect of the BDNF genotype on behavior. We determined the BDNF genotype and performance on the Compound Remote Associate (CRA) task as a common measure of creativity in 76 healthy university students. In our main analyses, we did not find significant differences between met-carriers (n = 30) and non-met carriers (n = 46). In a secondary analysis, we found that met-carriers had a slower solution time (medium effect size) for items of medium difficulty. Our results suggest that met-carriers and non-met-carriers do not generally differ regarding their creativity, but non-met-carriers may have a certain advantage when it comes to moderately difficult problems. The wider literature suggests that both genetic variants come with advantages and disadvantages. Future research needs to sharpen our understanding of the disadvantages and, potentially, advantages met allele carriers may have.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy |
UniBE Contributor: |
Hertenstein, Elisabeth, Maier, Jonathan Gabriel, Schneider, Carlotta Louisa |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1932-6203 |
Publisher: |
Public Library of Science |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
14 Sep 2023 14:05 |
Last Modified: |
29 Oct 2023 02:23 |
Publisher DOI: |
10.1371/journal.pone.0291397 |
PubMed ID: |
37703265 |
BORIS DOI: |
10.48350/186308 |
URI: |
https://boris.unibe.ch/id/eprint/186308 |
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