Intracranial neoplasia in 61 cats: localisation, tumour types and seizure patterns

Tomek, Ales; Cizinauskas, Sigitas; Doherr, Marcus; Gandini, Gualtiero; Jaggy, André (2006). Intracranial neoplasia in 61 cats: localisation, tumour types and seizure patterns. Journal of feline medicine and surgery, 8(4), pp. 243-53. London: Sage 10.1016/j.jfms.2006.01.005

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The purpose of this study was to analyse retrospectively a feline population with intracranial neoplastic diseases, to document seizure patterns in these animals and to determine whether partial seizures were more frequently associated with structural brain lesions then generalised seizures. In addition, a comparison was made within the population with intracranial neoplasia between two groups of cats: one with and one without seizures. Special emphasis was given to the evaluation of tumour type, localisation and size of the lesion and its correlation with seizure prevalence. Sixty-one cats with histopathological diagnosis of intracranial tumour were identified. Fourteen cats (23%; group A) had a history of seizure(s). Forty-seven cats (77%; group B) had no history of seizure(s). Generalised tonic-clonic seizures were seen in eight cats (57%) and were the most common seizure pattern in our cats with intracranial neoplasia. Clusters of seizures were observed in six cats. Status epilepticus was observed in one patient. The mean age of the cats was 7.9 years within group A (median 8.5) and 9.3 years (median 10) within group B. The cats with lymphoma within both groups were significantly younger than cats with meningioma. In both groups meningioma and lymphoma were confirmed to be the most frequent tumour type, followed by glial cell tumours. The prevalence of the seizures in patients with glial cell tumours was 26.7%, 26.3% in patients with lymphomas and 15% in cases with meningiomas. In 33 cases (54.1%) the tumours were localised in the forebrain, 15 tumours (24.6%) were in the brainstem, four (6.6%) in the cerebellum and nine tumours (14.7%) had multifocal localisation. Parietal lobe and basal ganglia mostly affected group A. In group B tumours were most frequently located in the parietal and frontal lobes as well as in the diencephalon. A positive association was documented between the localisation of a tumour in the forebrain and seizure occurrence.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DVK - Clinical Research (discontinued)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research

UniBE Contributor:

Tomek, Ales; Doherr, Marcus and Jaggy, André

ISSN:

1098-612X

Publisher:

Sage

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:45

Last Modified:

03 Feb 2015 11:34

Publisher DOI:

10.1016/j.jfms.2006.01.005

PubMed ID:

16600653

Web of Science ID:

000239543900004

URI:

https://boris.unibe.ch/id/eprint/18633 (FactScience: 834)

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