Outcomes After Transcatheter Mitral Valve Replacement According to Regurgitation Etiology.

Perrin, Nils; Ben Ali, Walid; Ludwig, Sebastian; Duncan, Alison; Weimann, Jessica; Nickenig, Georg; Tanaka, Tetsu; Coisne, Augustin; Vincentelli, Andre; Makkar, Raj; Webb, John G; Akodad, Mariama; Muller, David W M; Jansz, Paul; Praz, Fabien; Reineke, David; Wild, Mirjam G; Hausleiter, Jörg; Goel, Sachin S; Denti, Paolo; ... (2024). Outcomes After Transcatheter Mitral Valve Replacement According to Regurgitation Etiology. The Annals of Thoracic Surgery, 117(5), pp. 958-964. Elsevier 10.1016/j.athoracsur.2023.08.033

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BACKGROUND

Whether transcatheter mitral valve replacement (TMVR) devices perform similarly with respect to the underlying mitral regurgitation (MR) etiology remains unelucidated yet. The aim of the present analysis was to assess outcomes of TMVR according to the MR underlying etiology among the CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry (CHOICE-MI) registry.

METHODS

Out of 746 patients, 229 (30.7%) patients underwent TMVR. The study population was subdivided according to primary, secondary or mixed MR. Patients with mitral annular calcification were excluded. The primary study endpoint was a composite endpoint of all-cause mortality or hospitalisation for heart failure at 1 year. Secondary study endpoints included all-cause and cardiovascular mortality at 1 year, New York Heart Association functional class and residual MR, both at discharge and 1 year.

RESULTS

The predominant MR etiology was secondary MR (58.4%), followed by primary MR (28.7%), and mixed MR (12.9%). Technical success was similar according to MR etiology as was procedural mortality. Discharge echocardiography revealed residual MR 2+ in 11.3%, 3.7%, and 5.3% of patients with primary, secondary, and mixed MR, respectively (P=0.1). MR elimination was similar in all groups up to the 1-year follow-up. There was no difference in terms of primary combined outcome occurrence according to MR etiology. One-year all-cause mortality was reported in 28.8%, 24.2% and 32.1% of the patients with primary, secondary and mixed MR (P=0.07), respectively.

CONCLUSIONS

In our study, we did not find differences in short- and 1-year outcomes after TMVR according to MR etiology.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Heart Surgery

UniBE Contributor:

Praz, Fabien Daniel, Reineke, David Christian, Wild, Mirjam Gauri

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1552-6259

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

18 Sep 2023 14:21

Last Modified:

16 Sep 2024 00:25

Publisher DOI:

10.1016/j.athoracsur.2023.08.033

PubMed ID:

37717882

Uncontrolled Keywords:

medical therapy mitral annulus calcification mitral regurgitation mitral valve surgery transcatheter mitral valve implantation

BORIS DOI:

10.48350/186376

URI:

https://boris.unibe.ch/id/eprint/186376

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