Martini, Tatiana; Rios, Daniela; Dionizio, Aline; Cassiano, Luiza de Paula Silva; Silva, Cíntia Maria de Souza E; Taira, Even Akemi; Ventura, Talita Mendes Oliveira; Câmara, João Victor Frazão; Araujo, Tamara Teodoro; Magalhães, Ana Carolina; Saads Carvalho, Thiago; Baumann, Tommy; Lussi, Adrian; Oliveira, Ricardo Brandt de; Palma-Dibb, Regina Guenka; Buzalaf, Marília Afonso Rabelo (2023). Acquired enamel pellicle protects gastroesophageal reflux disease patients against erosive tooth wear. Brazilian oral research, 37, e085. Sociedade Brasileira de Pesquisa Odontológica 10.1590/1807-3107bor-2023.vol37.0085
|
Text
document.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (414kB) | Preview |
The objective of this study was to compare the protein profile of the acquired enamel pellicle (AEP) formed in vivo in patients with or without gastroesophageal reflux disease (GERD), and with or without erosive tooth wear (ETW). Twenty-four volunteers were divided into 3 groups: 1) GERD and ETW; 2) GERD without ETW; and 3) control (without GERD). The AEP formed 120 min after prophylaxis was collected from the lingual/palatal surfaces. The samples were subjected to mass spectrometry (nLC-ESI-MS/MS) and label-free quantification by Protein Lynx Global Service software. A total of 213 proteins were identified, or 119, 92 and 106 from each group, respectively. Group 2 showed a high number of phosphorylated and calcium-binding proteins. Twenty-three proteins were found in all the groups, including 14-3-3 protein zeta/delta and 1-phosphatidylinositol. Several intracellular proteins that join saliva after the exfoliation of oral mucosa cells might have the potential to bind hydroxyapatite, or participate in forming supramolecular aggregates that bind to precursor proteins in the AEP. Proteins might play a central role in protecting the dental surface against acid dissolution.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry |
UniBE Contributor: |
Saads Carvalho, Thiago, Baumann, Tommy, Lussi, Adrian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1807-3107 |
Publisher: |
Sociedade Brasileira de Pesquisa Odontológica |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
25 Sep 2023 16:48 |
Last Modified: |
29 Oct 2023 02:24 |
Publisher DOI: |
10.1590/1807-3107bor-2023.vol37.0085 |
PubMed ID: |
37729290 |
BORIS DOI: |
10.48350/186438 |
URI: |
https://boris.unibe.ch/id/eprint/186438 |
Actions (login required)
 |
Edit item |