Neurodegenerative diseases in domestic animals: a comparative review

Sisó, S; Hanzlícek, D; Fluehmann, G; Kathmann, I; Tomek, A; Papa, V; Vandevelde, M (2006). Neurodegenerative diseases in domestic animals: a comparative review. Veterinary journal, 171(1), pp. 20-38. Amsterdam: Elsevier 10.1016/j.tvjl.2004.08.015

Text 1-s2.0-S1090023304001844-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB)

Neurodegenerative diseases are characterised by selective damage to specific neurons in the nervous system. Interest in such diseases in humans has resulted in considerable progress in the molecular understanding of these disorders in recent decades. Numerous neurodegenerative diseases have also been described in domestic animals but relatively little molecular work has been reported. In the present review, we have classified neurodegenerative disease according to neuroanatomical criteria. We have established two large groups, based on whether the neuronal cell body or its axon was primarily affected. Conditions such as motor neuron diseases, cerebellar degenerations and neuroaxonal dystrophies are discussed in terms of their clinical and neuropathological features. In the most studied disorders, we also present what is known about underlying pathomechanisms, and compare them with their human counterparts. The purpose of this review is to re-kindle interest in this group of diseases and to encourage veterinary researchers to investigate molecular mechanisms by taking advantage of current diagnostic tools.

Interest & Impact

Downloads

0 since deposited on 04 Oct 2013
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item